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Calcitonin gene-related protein

A fully amorphous (glassy) freeze-dried product, consisting of 5% of a calcitonin gene-related protein (CGRP), 95% lactose and 3% residual water, was heated gently in a sealed DSC capsule. Its Tg is shown by the endothermic step in Scan 1 of Figure 4. Heating beyond Tg makes a material susceptible to more or less rapid physical and/or chemical... [Pg.179]

Fouchereau-Peron, M., Duvail, L., Michel, C., Gildberg, A., Batista, I., and Gal, Y. I. (1999). Isolation of an acid fraction from a fish protein hydrolysate with a calcitonin-gene-related-peptide-like biological activity. Biotechnol. Appl. Biochem. 29, 87-92. [Pg.100]

Kapas, S. Clark, A.J. Identification of an orphan receptor gene as a type 1 calcitonin gene-related peptide receptor. Biochem. Biophys. Res. Commun. 1995, 217, 832-838. Wilson, S. Bergsma, D.J. Chambers, J.K. et al. Orphan G-protein-coupled receptors the next generation of drug targets Br. J. Pharmacol. 1998, 125, 1387-1392. [Pg.3127]

CALCITONIN GENE-RELATED PEPTIDE RECEPTOR AGONISTS act at a number of related G-protein-coupled receptor subtypes. Human calcitonin gene-related peptide (CGRP) itself, is found in two forms, aCGRP (CGRP-I) and... [Pg.59]

Calcitonin gene-related peptide Opiate (mu) Protein kinase C... [Pg.187]

A mixture of high concentrations of cAMP and cAMP-dependent protein kinase increased the open probability of Kca channels reconstituted in a lipid bilayer (Savaria et al, 1992). p-Adrenergic stimulation increased Kca channel activity in whole-cell clamped rat myometrium (Anwer et al., 1992). In rabbit mesenteric arteries, calcitonin gene-related peptide (CGRP) appears to activate K xp channels through the mediation of protein kinase A (Quayle et al., 1994). These studies suggest that elevations in [cAMP] could hyperpolarize smooth muscle by opening K a or K xp channels. [Pg.230]


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See also in sourсe #XX -- [ Pg.143 ]




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