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LDLR-related protein

Apolipoprotein E (apoE) is an important lipid transport protein in human plasma and brain. It mediates hepatic clearance of remnant lipoproteins as a high-affin-ity ligand for the low-density lipoprotein receptor (LDLR) family, including LDLR, LDLR-related protein (LRP), and cell surface heparan sulfate PGs (71). In the liver, heparan sulfate PGs facilitate the interaction of remnant particles with LRP, which is known as the heparan sulfate PG-LRP pathway, in which apoE initially interacts... [Pg.240]

Mice with double KO (dKO) to LDLr related protein 5 and Apo E have severe hypercholesterolemia, and advanced atherosclerosis compaired to Apo E KO mice (359). LDLr related protein-1 mediates suppression of SMC migration induced by PDGF, and prevents atherosclerosis by controlling PDGF receptor activation by forming a complex with PDGF receptor (360). [Pg.132]

SorLA Sorting protein-related receptor containing LDLR class A repeats... [Pg.54]

See other pages where LDLR-related protein is mentioned: [Pg.762]    [Pg.762]    [Pg.706]    [Pg.308]    [Pg.706]    [Pg.271]    [Pg.347]    [Pg.387]    [Pg.284]    [Pg.64]    [Pg.328]   
See also in sourсe #XX -- [ Pg.240 ]



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