RING finger

Parkin is a ubiquitin ligase encoded by a gene affected in autosomal recessive juvenile parkinsonism (AR-JP). This gene is located on chromosome 6 and encodes a protein of 465 amino acid residues with moderate similarity to ubiquitin at the amino terminus and a RING-finger motif at the carboxy terminus. 

Goncyy Their molecular nature is completely different. PAR-3 is a PDZ-containing protein that has Bazooka and ASIP as Drosophila and mammalian cousins, respectively (Izumi et al 1998, Kuchinke et al 1998). PAR-2 is a ring-finger containing protein that does not have a characterized Drosophila or mammalian orthologue. 

Thomas Cbl is a ring finger protein which is involved in down-regulation of the receptor. This didn t fall out of the original screen. Are there mutants in Cbl as well ... 

Extensor muscle of the index finger. Variations, a, Accessory muscle to the ring finger, b to e, Accessory manual muscle of several forms. From Barry J. Anson, Atlas of Human Anatomy, p. 160. 

RING Fingers and Relatives Determinators of Protein Fate... 

The term RING finger was first coined by Freemont and colleagues referring to a gene product in the MHG class I locus [22]. Their apparent exuberance led to the... 

Remarkably, at the same time, several groups independently determined that there was a previously undiscovered component to the SCF complex - a small non-canonical RING finger protein known variably as Rbxl, Rod or Hrtl [36-... 

Perhaps, analogous to Bardl, MdmX may modulate the E3 activity of Mdm2 towards p53 through dimerization (see below). Ironically, PML (promyleocytic 7eu-kemia), one of the first RING finger proteins to be characterized has, to date, not shown E3 activity (see below). 

For both Cnot4 and c-Gbl there are several points of contact between the E2 (shown in red) and the RING finger (shown in blue in Figure 4.3A and B). These include residues in the first a-helix of the E2 and two loops that extend down from the core... 

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