Differentiation-related proteins

The differentiation effect of lycopene was associated with elevated expression of several differentiation-related proteins, such as cell surface antigen (CD14), oxygen burst oxidase and chemotactic peptide receptors (Amir et al., 1999). Recently, it has also been reported that lycopene was also able to stimulate the differentiation marker alkaline phosphatase activity in... 

ADPH was not identified as a major MFGM protein until recently because it co-migrates with the glycoprotein known as PAS 6/7. ADPH was known previously as adipocyte differentiation-related protein (ADRP) because it is expressed early during adipocyte differentiation and was believed to be expressed only in adipocytes (Jiang and Serrero, 1992). Since then, ADPH has been detected in a large number of tissues and cell types, where it invariably is associated with intracellular lipid droplets (Heid et al., 1996 1998 Brasaemle et al., 1997). 

Brasaemle, D.L., Barber, T., Wolins, N.E., Serrero, G., Blanchette-Mackie, E.J., Londos, C. 1997. Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein. J. Lipid Res. 38, 2249-2263. 

Heid, H.W., Schnolzer, M., Keenan, T.W. 1996. Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane. Biochem. J. 320, 1025-1030. 

Jiang, H-P., Serrero, G. 1992. Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein. Proc. Natl. Acad. Sci. USA 89, 7856-7860. 

Baba, M., Nakaigawa, N., Ishiguro, H., Hamada, K., Inayama, Y, Kishida, T., Hattori, K., etaJ. (2005). Gene expression analysis of renal carcinoma adipose differentiation-related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma. J. Pathol. 205, 377-387. 

Perilipins Little is known about proteins on the surface of mammalian intracellular LD. Two groups of proteins whose association with LD in animal cells is well documented are the perilipins and adipocyte differentiation related protein (ADRP) (reviewed in Ref. [156]). The human ortholog of ADRP has been termed adipophilon [157]. Other proteins at or near the surface of the LD of adipocytes include the capsular proteins [158-160] and vimentin [153, 161]. Furthermore, certain enzymes, e.g. eicosanoid-forming enzymes, associate with LD in various types of cells [162-164]. 

J. Gao, H. Ye, and G. Serrero, Stimulation of adipose differentiation related protein (ADRP) expression in adipocyte precursors by long-chain fatty acids, J. 

J. Gao and G. Serrero, Adipose differentiation related protein (ADRP) escpressed in transfected COS-7 cells selectively stimulates long chain fatty acid uptake, J. Biol. Chem., 1999, 274, 16825-16830. 

D. Marchesan, M. Rutberg, L. Anders-SON, L. Asp, T. Larsson, J. Boren, B.R. Johansson, and S.-O. Oloesson, A phospholipase D-dependent process forms lipid droplets containing caveolin, adipocyte differentiation-related protein (ADRP), and vimentin in a cell-free system, J. 

Keenan, Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane,... 

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