Pancreatic lipase-related proteins

The pancreas produces several lipases, the classical lipase (pancreatic lipase, PL) and the pancreatic lipase-related proteins 1 (PLRP1) and 2 (PLRP2). In addition there is a protein named colipase, which is necessary for the activity of PL. PLRP1 seems to be devoid of lipase activity, while PLRP2... 

Perez de la Cruz Moreno M, Oth M, Deferme S, Lammert F, Tack J, Dressman J and Augustijns P (2006) Characterization of fasted-state human intestinal fluids collected from duodenum and jejunum. J Pharm Pharmacol 58(8) 1079-1089 Reboul E, Berton A, Moussa M, Kreuzer C, Crenon I and Borel P (2006) Pancreatic lipase and pancreatic lipase-related protein 2, but not pancreatic lipase-related protein 1, hydrolyze retinyl palmitate in physiological conditions. Biochim Biophys Acta 1761(1 ) 4—10 Scheele G, Bartelt D and Biegzr W (1981) Characterisation of human exocrine pancreatic proteins. Gastroent 80(3) 461 473... 

De Caro, J., Carriere, F., Barboni, P., Gil-LER, T, Verger, R. and de Caro, A. (1998) Pancreatic lipase-related protein 1 (PLRPl) is present in the pancreatic juice of several species. Biochim. Biophys. Acta 1387, 331-341. 

Gili.er, T, Buchwald, P., Blum-Kaelin, D. and Hunziker, W. (1992) Two novel human pancreatic lipase related proteins, hPLRPl and hPLRP2. Differences in colipase dependence and in lipase activity. J. Biol. Chem. 267, 16509-16516. 

Lowe, M.E. (2000) Properties and function of pancreatic lipase related protein 2. Bio-chimie 82, 997—1004. 

Roussel, A., Yang, Y, Ferrato, F., Verger, R., Cambillau, C. and Lowe, M. (1998b) Structure and activity of rat pancreatic lipase-related protein 2. J. Biol. Chem. 273, 32121-32128. 

The purification and properties of porcine pancreatic lipase have been discussed in a recent review (142). Only the most significant facts related to the protein nature of the enzyme will therefore be presented here. 

C. and Verger, R. (1998) Structural basis for the substrate selectivity of pancreatic lipases and some related proteins. Biochim. Biophys. Acta 1376, 417—432. 

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