Production control

A first comprehensive round robin test described in 4.1 which is open to all interested parties will be followed periodically by round robin tests in a reduced extent to ensure the further harmonisation of measurement procedures. The check of measurering equipments and procedures is an inalienable requirement for the further steps for providing the users with constant film quality. Together with sample tests performed by BAM as indicated in section 4.2 and and the production control by the manufacturer it will be possible to survey the film systems whether they meet the requirements of one of the film classes of EN 584-1. 

That Global Approach requires that the proeedures to prove compliance of a product with the essential requirements in New Approach directives should be chosen from amongst nine procedures referred to as modules. These modules range from a procedure which does not involve the intervention of a third party, the manufacturer s own production control, to procedures with full intervention of that party at both levels, at the design and at the manufacturing stage. 

That set of modules includes alongside the traditional procedures related to product control, quality assurance procedures for conformity assessment. The intervention of a third party in these procedures comprises an initial audit of the manufacturer s quality system which must include both the specific technological aspects of the products concerned and the methodology of the quality assurance procedures. Furthermore the manufacturers are subject to periodic audits to ensure that the systems are maintained. Finally, on the occasion of unexpected visits, the notified body can carry out tests on the products. 

The use of these techniques is an important element of industrial policy since they contribute to the creation of a business friendly regulatory environment allowing the combination of measures taken for internal organisational reasons and obligations of certification without lowering the level of safety to be achieved. Wlienever possible a choice between product control and quality assurance procedures is offered to manufacturers. 

In general, the geometric properties of the natural fibers are highly variable from fiber to fiber, both within a given lot and among lots of the same fiber type. In the synthetic fibers, the geometric properties are extremely uniform in view of the production control possible in a chemical plant but not in an agricultural product. 

Establish a Recordkeeping System. It has always been important for the food manufacturer to maintain records of ingredients, processes, and product controls so that an effective trace and recall system is available when necessary. 

No less important are specifications issued by iadustrial consumers. Consumers are making purchasiag decisions on the basis of the manufacturer s processiag capabiUty and requiring the iaspection of production control charts and data. 

The amounts and types of Hpids used in skin-care products control their appHcation properties. Methods for assessing these characteristics using expert paneHsts have been described (47). 

Production Controls The nature of the produc tion control logic differs greatly between continuous and batch plants. A good example of produc tion control in a continuous process is refineiy optimization. From the assay of the incoming crude oil, the values of the various possible refined products, the contractual commitments to dehver certain products, the performance measures of the various units within a refinery, and the hke, it is possible to determine the mix of produc ts that optimizes the economic return from processing this crude. The solution of this problem involves many relationships and constraints and is solved with techniques such as linear programming. 

Vibrating conveyors employing direc t contacting of sohds with hot, humid air have also been employed for the agglomeration of fine powders, chiefly for the preparation of agglomerated water-dispersible food products. Control of inlet-air temperature and dew point permits the uniform addition of small quantities of liquids to sohds by con-... 

The availability of a resource depends on the degree to which it is localised in one or a few countries (making it susceptible to production controls or cartel action) on the size of the reserves, or, more accurately, the resource base (explained shortly) and on the energy required to mine and process it. The influence of the last two (size of reserves and energy content) can, within limits, be studied and their influence anticipated. 

The requirement in clause 4.13.1 of ISO 9001 requires the supplier s nonconforming product controls to provide for notifying the functions concerned. This supplementary... 

Three types of control plan are required. During the product design and development phase, a prototype control plan is required to be produced. During the process design and development phase, a pre-launch or pilot production control plan is required, and during the product and process validation phase, the production control plan is to be issued. 

The configuration of the amine was retained, except in the case of amino acid derivatives, which racemized at the stage of the pyridinium salt product. Control experiments showed that, while the starting amino acid was configurationally stable under the reaction conditions, the pyridinium salt readily underwent deuterium exchange at the rz-position in D2O. In another early example, optically active amino alcohol 73 and amino acetate 74 provided chiral 1,4-dihydronicotinamide precursors 75 and 76, respectively, upon reaction with Zincke salt 8 (Scheme 8.4.24). The 1,4-dihydro forms of 75 and 76 were used in studies on the asymmetric reduction of rz,>S-unsaturated iminium salts. 

For examination of finished product, where time is not a limiting factor, more precise and accurate methods may be used to advantage for checking the reliability of production control methods, for settling claims concerning quality and condition, for tracing the causes of quality deterioration, and for fixing responsibility. 

An interesting case of product-controlled simple diastereoselectivity has been reported103. [l-[Methyl(nitrosoamino)]-2-propenyl]lithium adds to benzaldehyde at — 78°C to give the amino alcohol with an anti/syn ratio of 65 35, but equilibration of the reversible reaction at room temperature leads exclusively to the more stable, vv -product. 

From a practical aspect, when the expression quality control is use, we tend to think in terms of a good or excellent product. In industry, it is one that fulfills customer s expectations. These expectations or standards of performance are based on the intended use and selling price of the product. Control is the process of regulating or directing an activity to verify its conformance to a standard/specification and to take corrective action if required. Therefore QC is the regulatory testing process for those activities that measure a product s performance, compare that performance with established standards/specifications, and pursue corrective action regardless of where those activities occur. 

Fruit and vegetable juices packed with 21-26 in. of vacuum and stored in uncoated aluminum cans caused severe corrosion as shown in Table III. The corrosion rate brought about by the juices depends more on the nature of the organic acid present and the buffering capacity of the juice than on the total titratable acidity (11). The use of coated aluminum containers considerably minimized corrosion problems. Product control under extended storage conditions may be achieved by using specific chemical additives. However, more work is needed in this area before final conclusions can be reached. 

GL30 Pharmacovigilance list of terms Pharmacovigilance of Veterinary Medicinal Products controlled list of terms... 

Pharmaceutical products are not sold or supplied before a Qualified Person has certified that each production batch has been produced and controlled in accordance with the requirements of the Marketing Authorisation and any other regulations relevant to the production, control and release of medicinal products. 

Since LFR s generally run under temperatures, viscosities and other parameters varying as one proceeds downstream, it follows that process and product control can be more complicated than with a CSTR. 

After the dominant independent variables have been brought under control, many small and poorly characterized ones remain that limit further improvement in modeling the response surface when going to full-scale production, control of experimental conditions drops behind what is possible in laboratory-scale work (e.g., temperature gradients across vessels), but this is where, in the long term, the real data is acquired. Chemistry abounds with examples of complex interactions among the many compounds found in a simple synthesis step,... 

While the above examples demonstrate that product control to a significant extent is possible in oxythallation by careful choice of substrate or reaction conditions, the synthetic utility of oxythallation has been illustrated most convincingly by the results obtained with highly ionic thallium(III) salts, especially the nitrate (hereafter abbreviated TTN). Unlike the sulfate, perchlorate, or fluoroborate salts (165), TTN can easily be obtained as the stable, crystalline trihydrate which is soluble in alcohols, carboxylic acids, ethers such as dimethoxyethane (glyme), and dilute mineral acids. Oxidations by TTN can therefore be carried out under a wide variety of experimental conditions. 

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