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1-based approach

Plenary 2. S A Asher et al, e-mail address asher ,vms.cis.pitt.edu/asher+ (RRS, TRRRS). UV RRS is used to probe methodically the secondary structure of proteins and to follow unfolding dynamics. Developing a library based approach to generalize the mediod to any protein. [Pg.1217]

Additionally, as in all Tl-based approaches, the free energy differences are linear functions of the potential. Thus non-rigorous decompositions may be made into contributions from the different potential energy terms, parts of system and individual coordinates, providing valuable insight into the molecular mechanisms of studied processes [8, 9, 10). [Pg.166]

The program system COBRA [118, 119] can be regarded as a rule- and data-based approach, but also applies the principles of fragment-based (or template-based) methods extensively (for a detailed description sec Chapter 11, Sections 7.1 and 7.2 in the Handbook). COBRA uses a library of predefined, optimized 3D molecular fragments which have been derived from crystal structures and foi ce-field calculations. Each fi agment contains some additional information on... [Pg.98]

Simulated Annealing-based solutions [19] are conceptually the same as Genetic Algorithm-based approaches. However, the SA-based techniques, in our experience, are more sensitive to the initial settings of the parameters. Nevertheless, once the correct ones are found, the method can achieve the efficiency of GA-based solutions. We must point out that SA-based solutions have never outperformed the GA-based ones in our studies. Much of what has been mentioned regarding the GA-based solutions is also relevant for the SA technique, particularly, with respect to the cost functions. [Pg.219]

The Rekker approach is still used with revised Z/ systems, e.g., in the software program Z/SYBYL [8]. Over recent decades various other substructure-based approaches have been developed that are mostly implemented and available as computer programs. [Pg.493]

The Japanese program system AlPHOS is developed by Funatsu s group at Toyo-hashi Institute of Technology [40]. AlPHOS is an interactive system which performs the retrosynthetic analysis in a stepwise manner, determining at each step the synthesis precursors from the molecules of the preceding step. AlPHOS tries to combine the merits of a knowledge-based approach with those of a logic-centered approach. [Pg.576]

Rule-based Approaches Using Secondary Structure Prediction... [Pg.536]

Ihe rule-based approach to protein structure prediction is obviously very reliant on th quality of the initial secondary structure prediction, which may not be particularly accurate The method tends to work best if it is known to which structural class the protein belongs this can sometimes be deduced from experimental techniques such as circular dichroism... [Pg.537]

A major potential drawback with cluster analysis and dissimilarity-based methods f selecting diverse compounds is that there is no easy way to quantify how completel one has filled the available chemical space or to identify whether there are any hole This is a key advantage of the partition-based approaches (also known, as cell-bas( methods). A number of axes are defined, each corresponding to a descriptor or son combination of descriptors. Each axis is divided into a number of bins. If there are axes and each is divided into b bins then the number of cells in the multidimension space so created is ... [Pg.701]

Two noncalculus-based approaches to discovering the Beer-Lambert law are found in the following papers. [Pg.458]

In the previous section we described several internal methods of quality assessment that provide quantitative estimates of the systematic and random errors present in an analytical system. Now we turn our attention to how this numerical information is incorporated into the written directives of a complete quality assurance program. Two approaches to developing quality assurance programs have been described a prescriptive approach, in which an exact method of quality assessment is prescribed and a performance-based approach, in which any form of quality assessment is acceptable, provided that an acceptable level of statistical control can be demonstrated. [Pg.712]

In a performance-based approach to quality assurance, a laboratory is free to use its experience to determine the best way to gather and monitor quality assessment data. The quality assessment methods remain the same (duplicate samples, blanks, standards, and spike recoveries) since they provide the necessary information about precision and bias. What the laboratory can control, however, is the frequency with which quality assessment samples are analyzed, and the conditions indicating when an analytical system is no longer in a state of statistical control. Furthermore, a performance-based approach to quality assessment allows a laboratory to determine if an analytical system is in danger of drifting out of statistical control. Corrective measures are then taken before further problems develop. [Pg.714]

Once a control chart is in use, new quality assessment data should be added at a rate sufficient to ensure that the system remains in statistical control. As with prescriptive approaches to quality assurance, when a quality assessment sample is found to be out of statistical control, all samples analyzed since the last successful verification of statistical control must be reanalyzed. The advantage of a performance-based approach to quality assurance is that a laboratory may use its experience, guided by control charts, to determine the frequency for collecting quality assessment samples. When the system is stable, quality assessment samples can be acquired less frequently. [Pg.721]

Historically, the discovery of one effective herbicide has led quickly to the preparation and screening of a family of imitative chemicals (3). Herbicide developers have traditionally used combinations of experience, art-based approaches, and intuitive appHcations of classical stmcture—activity relationships to imitate, increase, or make more selective the activity of the parent compound. This trial-and-error process depends on the costs and availabiUties of appropriate starting materials, ease of synthesis of usually inactive intermediates, and alterations of parent compound chemical properties by stepwise addition of substituents that have been effective in the development of other pesticides, eg, halogens or substituted amino groups. The reason a particular imitative compound works is seldom understood, and other pesticidal appHcations are not readily predictable. Novices in this traditional, quite random, process requite several years of training and experience in order to function productively. [Pg.39]

In a biotechnology-based approach, Japanese workers have reported on the microbial conversion of 2-methylnaphthalene to both 2-methyl-1-naphthol and menadione by Jiodococcus (64). The intermediate 2-methyl-1-naphthol can readily be converted to menadione by a variety of oxidizing agents such as heteropoly acids (65) and copper chloride (66). A review of reagents for oxidizing 2-methylnaphthalene and naphthol is available (67). [Pg.155]

J) the atmosphere inside a particular reactor contains hydrogen, and (4) the reactor is at a high temperature, the additional fact that air has leaked into the feed to the reactor leads to the conclusion that an explosion can take place. The conclusion is based on applying deductive logic to the known facts. This is representative of the logic-based approach to knowledge-based systems. [Pg.531]

The certainty factor approach has been among the more popular rule-based approaches to uncertainty. However, although it is easy to apply given the individual CFs, acquiring the raw CFs from the experts is often quite difficult. Further, although the formulas for CF combination are mathematically appealing, they often have no relation to the ways in which experts combine evidence to arrive at conclusions. Some of the task-specific approaches discussed later address uncertainty combination in a more intuitive way (35). [Pg.534]

J. R. Whiteley andj. F. Davis, "QuaHtative Interpretation of Sensor Patterns using a Similarity-Based Approach," paper presented at the IFAC Symposium on On-Eine Fault Detection and Supervision in the Chemical Process Industries, Newark, Del., Apr. 1992. [Pg.541]

The first three of these are solely X T.E-based approaches, involving a series of simple distillation operations and recycles. The final approach also relies on distillation (X T.E), but also exploits another physical phenomena, liqnid-hqnid phase formation (phase splitting), to assist in entrainer recovery. This approach is the most powerful and versatile. Examples of industrial uses of azeotropic distillation grouped by method are given in Table 13-18. [Pg.1306]


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A Design Approach Based on Irreversibility

A RISK-BASED APPROACH TO PRE-STARTUP SAFETY REVIEW

A Systematic Approach for Synthesis of an Integrated Palm Oil-Based Biorefinery

A behaviour-based approach to continuous quality improvement

ALARP risk-based approach

Acid-base approach

Acid-base approach (van Oss-Good method)

Actively caring person-based approach

Acute Ischemic Stroke: An Evidence-based Approach, Edited by David M. Greer

Adhesion-based approach

Alternative Strategy Property-based Approach

An Improved Model based on a Fracture Mechanics Approach

An Overview of the Risk-based Approach to PSSR

Approach 3 Based on theories for each indicator

Approach Based on Analogy between Momentum and Mass Transfer

Approach Based on Linear Elastic Fracture Mechanics

Approach based on improved urban roughness and fluxes

Approaches Based on Continuum Solvation Models

Approaches to Structure-Based Ligand Design

Artificial neural networks based models approach, applications

Atom-based approach

Bacterial Protein Biomarker Discovery A Focused Approach to Developing Molecular-Based Identification Systems

Band theory orbital-based approach

Base-budgeting approach

Based Design Approach

Based on the LBS Approach

Behavior-based approach/programs

Behavior-based approach/programs integration

Bio-Based Synthetic Approach

Biologically based approach

Bioprocessing Approaches to Synthesize Bio-based Surfactants and Detergents

Buckypaper-based Approaches

Capacity-based approach

Carbocation-Based Approaches

Carbohydrate-based chiron approach

Cellular-based approaches

Challenges of Fragment-Based Approaches

Chemical approach based on molecular orbital theory

Chemical education context-based approaches

Chemical knowledge-based approaches

Chemistry context-based approaches

Chemistry-based approaches

Chemometrics-based approach

Chiral auxiliary based approaches

Chiral auxiliary based approaches group

Chiral auxiliary based approaches reaction

Competitive Intelligence-based Lead Generation and Fast Follower Approaches

Competitive intelligence based approach

Component-based approaches

Computational based approach

Constraints-Based Approach to Functional Analysis

Context-based approaches, teaching

Data interpretation knowledge-based system approaches

Descriptor-Based Approaches

Diversity-based approaches

EXPOSURE-BASED APPROACHES

Educational research context-based approaches

Environmental policy market-based approaches

Equilibrium constant-based approach

Equilibrium-based approach

Essential Physiological Biochemistry: An organ-based approach Stephen Reed

Essential Physiological Biochemistry: An organ-based approach Stephen Reed 2009 John Wiley Sons, Ltd

Fatigue Life Prediction Based on Local Strain Approach

Fatigue stress based approach

Feasibility Analysis An RCM-Based Approach

Fiber-optic-based fluorescence sensing approaches

Field-based approaches

Force field based simulation approaches

Formal Metadata Based Approaches

Fragment-Based Approaches in Virtual Screening

Fragment-Based Drug Discovery: A Practical Approach Edited by Edward R. Zartler and Michael J. Shapiro

Fragment-Based Drug Discovery: A Practical Approach Edited by Edward R. Zartler and Michael J. Shapiro 2008 John Wiley Sons, Ltd. ISBN

Fragment-based approach

Fragment-based modelling approach

Fuzzy logic -based models approach, applications

Glycan-based therapeutic approaches

Goal-based approach

Goal-based approach advantages

Goal-based approach limitations

Goal-based approach safety objectives

Goal-based approach system safety assessment

Graph-based approaches

Grid-based approaches

Group-Based Liberal Approaches

Hazard-based approach

High throughput based approach

Homology-based approaches

Humanism Person-based approach

Hybridization-based approaches

Hydrogen bond descriptor-based approaches

Hydrogen separation membrane-based approaches

Image-based approach

Implants cellular-based approaches

Index-based approach

Inhibitors library-based approaches

Inkjet-based approach

Integrity-based approach

Interface between Transition Metal Oxides-Based Electrodes and Lithium Salts Electrolytes A Physicochemical Approach

Kinetics context-based approaches

Knowledge-based approach

Knowledge-based approaches, protein structure simulations

Knowledge-based scoring approaches

LC-MS-Based Approaches

Library synthesis substrate-based approach

Library-based approach

Ligand design fragment-based approaches

Ligand-based Combinatorial Design The RADDAR Approach

Ligand-based approach

Ligand-based approach predicting functional sites

Limitations to time-based approaches

Lipid-based formulations approach

Lipid-based formulations approach activity

Lipid-based formulations approach emulsions

Lipid-based formulations approach enhancement

Lipid-based formulations approach systems

Logistics time-based approaches

MORT-based approach

Malaria target-based approaches

Mass Spectrometry-Based Lipidomics Approaches

Mass defect filter-based approaches

Mechanism-based approach

Microarray model based approaches

Microelectromechanical systems based approaches

Model-based approach

Molecular Orbital (MO) approach to acid-base reactions

Molecular Recognition-Based Approach

Multiphonon-based approaches

Normal-Phase LC-MS-Based Approaches

Nucleic acid-based testing approach

Oligomer-based approaches

Omeprazole-based fast follower approaches

One-Stage Approach Based on a Silica Precursor with Ethylene Glycol Residues

Orbital (MO) approach to acid-base reactions

Organism-based approach

Other LC-MS-Based Approaches

Our Approach to High-Throughput Fragment-Based Docking

Overview of Printing-based Manufacturing Approaches for OTFTs

Packed beds structure-based approach

Pattern based multiple gene prediction approach

Peptide and Protein-based Approaches

Performance-based approach

Person-based approach to actively caring

Person-based approach/programs

Person-based approach/programs integration

Pharmaceutical manufacturing risk-based approaches

Polynomial Based Optimisation Framework - A New Approach

Population-based approaches

Precedence-based approaches

Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating

Prediction Power of Property-based Approaches

Prediction by restraint driven folding Evolutionary based approaches

Predictive Power of Substructure-based Approaches

Principal component analysis -based approach

Probability goal-based approach

Property-Based Approaches to Design Rules for Reduced Toxicity

Property-based approaches

Protein-based approach

Protein-based approach predicting functional sites

Rate-based approach

Rate-based approach for modeling

Rate-based approach reforming

Reaction Searching Using Fingerprints-Based Approach

Reagent-based domino approach

Regulatory Approaches Prescriptive and Goal-Based

Reversed-Phase LC-MS-Based Approaches

Review of Stability Criteria Based on Fundamental Approach

Review of Stability Criteria Based on Heuristic Approach

Rimonabant-based fast follower approach

Risk-Based Approaches to PSSR

Risk-based approach

Risk-based approach advantages

Risk-based approach disadvantages

Risk-based approach steps

Risk-based approach system safety assessment

Risk-based approaches groundwater assessment

Risk-based approaches metal contaminants

Risk-based development approach

Rodent Populations Enable a Population-Based Approaches to Toxicology

Rule-based Approach

Rule-based correlation approach

STANDARDIZATION OF ANTIGEN RETRIEVAL TECHNIQUES BASED ON THE TEST BATTERY APPROACH

Safety management system integrity-based approach

Scaffold substrate-based approach

Scaffold-based Classification Approach

Scenario based approach

Schiff base approaches

Science-Based Probability Approach

Selectivity potency-based approach

Semiempirical-estimation-based approach

Sequence-based approaches

Shotgun Lipidomics Direct Infusion-Based Approaches

Simultaneous or Consecutive Acid-Base Reactions A General Approach

Solid Phase Extraction-Based Selective Approaches

Space-based approaches

Structure-based Cheminformatics Approach to Virtual Screening The CoLiBRI Method

Structure-based approaches

Structure-based drug design approaches

Structure-based molecular design approaches

Structure-based searches, approaches

Substrate-based approaches

Substructure-based approaches

Tabu-Search-based approaches

Target-Based Approaches

Technology-based approach

The Biological Approach Phage-Display-Based Optimization

The Decision-Based Approach to Organic Chemistry

The Design of an Effective Natural-Products-Based Approach to Drug Discovery

The behavior-based approach

The molecular probe approach assessment of acid-base properties

The person-based approach

The person-based approach to actively caring

Thermodynamics context-based approaches

Thomas-Fermi-Dirac-based approaches

Time-based approach, pricing models

Time-based approaches

Trajectory based EPR simulation approach

Transformation-based approaches

Two Examples of Using a Risk-based Approach to PSSR Design

Unitary group approach based

Volume-based approach

Volume-based thermodynamics approach

What is a Risk-based Approach to PSSR

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