MDL Available Chemicals

MDL Available Chemicals Directory provided by MDL Information Systems Inc., San Leandro, CA, USA, http // www.mdl.com/products/ experiment/available chem dir. 

Most prediction tools for druglikeness use the MDL Available Chemicals Directory (ACD) [89] as a list of nondrugs and one of three databases as a list of drugs MDL Drug Data Report (MDDR) [89], MDL Comprehensive Medicinal Chemistry (CMC) [89], or Derwent World Drug Index (WDI) [90]. 

MDL Available Chemicals Directory database 2007, Symyx Technologies, Inc., Santa Clara, CA 95051, USA. 

MDL Available Chemicals Directory (MDL ACD). MDL Information Systems, San Leandro, CA. 

The.se databases have an important role to fill from a supply point of view, and mention should be made of the MDL Available Chemicals Directory (ACD), which coordinates the offerings of many suppliers. Containing over 240 catalogs representing over 500000 products and 2(X)000 substances, the ACD provides an efficient way to reliably source and comparison-shop for commercially available chemicals. The database contains all of the necessary information to select a vendor s product on the basis of a review of the purity, grade, and quantity desired, and then to place an order with the manufacturer or a local distributor. 

While not convincing from a statishcal perspective, the results in this section are consistent with a trend high-activity molecules published in the past decade of medicinal chemistry literature are more likely to be found in the large, hydrophobic and poor solubility corner of chemical property space. These results are not consistent with, for example, cell-based [41] and median-based [42] partihoning of biologically active compounds however, such analyses were performed in the presence of inactive compounds selected from MDDR[41] or ACD [42], with quite probably unrelated chemotypes. ACD, the Available Chemicals Directory [43], and MDDR, the MDL Drug Data Report [43], are databases commonly used by the pharmaceuhcal industry. 

Available Chemicals Directory (ACD) Documentation, Version 95.2, MDL Information Systems, Inc., 1995. 

Available Chemicals Directory (ACD, ACD screen) MDL 171 http //www.mdli.com... 

Synthetic chemical structures were obtained from the Available Chemicals Directory (ACD, MDL Information Systems Inc., San Leardo, CA, n 182 822) and a representative pool of test substances from the Synthetics database (Bayer AG, n not reported). 

The Available Chemicals Directory is distributed by MDL Information Systems Inc.,... 

ACD (Available chemical directory), Version 2001/ 01 MDL Information Systems, 2001, http //uwiv.OTcH.coOT. 

Available Chemicals Directory is available from MDL Information Systems Inc., San Leandro 94577, CA, and contains specialty bulk chemicals from commercial sources. Website www.mdli.com. 

Available Chemicals Directory MDL database Is a chemical database providing access to pricing and supplier information for more than 400,000 research-grade and bulk chemicals. Available at http //www.mdl.com. Accessed March 28. 2007. 

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