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Inhibitors library-based approaches

C. E. Lee, E. K. Kick, J. A. Ellman, General Solid-Phase Synthesis Approach to Prepare Mechanism-Based Aspartyl Protease Inhibitor Libraries. Identification of Potent Cathepsin D Inhibitors. J. Am. Chem. Soc 1998, 120, 9735-9747. [Pg.78]

Honma, T., Yoshizumi, T., Hashimoto, N., et al. (2001) A novel approach for the development of selective Cdk4 inhibitors library design based on locations of Cdk4 specific amino acid residues../. Med. Chem. 44, 4628-4640. [Pg.376]

We have developed and applied the ALTA (anchor-based library tailoring) approach to identify ATP-competitive inhibitors of EphB4 [99] (Eigure 17.5). ALTA is an automatic fragment-based procedure for focusing libraries of compounds. First, molecular fragments are docked and prioritized (i.e., anchors are selected based on a... [Pg.477]

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