Malaria target-based approaches

Within the malaria field, as mentioned, a few projects have delivered hits through target-based approaches (e.g., Pf (P. falciparum) DHODH). The DHODH project team, led by Prof. Margaret Phillips from the University of Texas South Western, ran a HTS of a compound collection against jy DHODH. They isolated several series of which one, a triazolopyrimidine, was selected for follow-up. This ultimately led to delivery of a preclinical candidate that, in 2014, delivered a positive proof of principle in a human challenge trial. This will be documented later as a specific case study. 

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