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Rimonabant-based fast follower approach

1) Identifying the metabolic weak spots on rimonabant and improving the metabolic stability to gain advantage of longer plasma half-life. [Pg.210]

Rimonabant CBi Ki 1.8 nM CB2Ki 514nM Plasma/brain ratio 1.2 [Pg.211]

2) Improving selectivity against CB2 receptors to avoid CB2 receptor-associated side effects. [Pg.211]

3) Restricting CBiR antagonists in the peripheral system to avoid CNS side effects. [Pg.211]

SAR analysis of rimonabant-based series compounds suggested the following  [Pg.211]


See other pages where Rimonabant-based fast follower approach is mentioned: [Pg.210]    [Pg.210]    [Pg.215]    [Pg.210]    [Pg.210]    [Pg.215]    [Pg.213]   
See also in sourсe #XX -- [ Pg.210 ]




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