SEARCH Articles Figures Tables 1-based approach A Design Approach Based on Irreversibility Approaches to Structure-Based Ligand Design Design Bases Design approach Ligand design fragment-based approaches Ligand-based Combinatorial Design The RADDAR Approach Property-Based Approaches to Design Rules for Reduced Toxicity Structure-based drug design approaches Structure-based molecular design approaches The Design of an Effective Natural-Products-Based Approach to Drug Discovery Two Examples of Using a Risk-based Approach to PSSR Design