Fragment-based approaches

Jahnke W, Erlanson DA (2006) Fragment-based approaches in dmg discovery. Wiley, New York... 

Fragment-Based Approaches in Drug Discovery (eds W. Jahnke and D. A. Erlanson), Wiley-VCH, Weinham, 2006, pp. 215-248. 

Jahnke, W., Erlanson, D.A. (Eds) Fragment-Based Approaches in Drug Discovery. Vol 34 in series Methods and Principles in Medicinal Chemistry (Series Eds R. Mannhold, H. Kubinyi, G. Folkers). Weinheim, Germany Wiley-VCH 2006. 

Huth, J.R., Sun, C. Utility of NMR in lead optimization fragment-based approaches. Comb. Chem. High. Throughput Screen. 2002, 5, 631-643. 

Wells, J.A. Tethering, in Fragment-based Approaches in Drug Discovery, ed. W. Jahnke, D.A. Erlanson, Wiley-VCH, Weinheim, 2006. pp 285-310. 

Erlanson, D. A. BaUinger, M. D. WeUs, J. A. In Fragment-based approaches in drug discovery. In Jahnke, W. Erlanson, D. A. editors. Wiley-VCH, Weinheim, Tethering, 285-308. 

Moriaud F, Doppelt-Azeroual O, Martin L et al (2009) Computational fragment-based approach at PDB scale by protein local similarity. J Chem Inf Model 49 280-294... 

Richards, N., Williams, P. B., and Tute, M. (1991) Empirical methods for computing molecular partition coefficients. I. Upon the need to model the specific hydration of polar groups in fragment based approaches. Int. J. Quant. Chem. 18, 299-316. 

Chilli, A., Williams, G, Smith, A. G, Blundell, T. L and Abell, C. (2006). Probing hot spots at protein-ligand binding sites a fragment-based approach using biophysical methods. Journal of Medicinal Chemistry 49, 4992-4500. 

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