Population-based approaches

It is noteworthy that the incidence of AKI in this study, 1.1 cases/10, 000, is 100 times less than that reported by Schneider et al [32A] using a population based approach. 

The NCEP guidelines for patient management are of two types. One is a population-based approach to reduce CHD risk, which includes recommendations to increase exercise (to expend 2000 calories/week)... 

RODENT POPULATIONS ENABLE A POPULATION-BASED APPROACH TO TOXICOLOGY... 

A population-based approach to reducing disease by reducing salt intake is a public health strategy directed at the whole population rather than those individuals considered to be at high risk. Such a strategy is based on the observation that a small reduction in risk of a large number of people may result in a large reduction in risk... 

Hanvelt et al. (1994) estimated the nationwide indirect costs of mortality due to HIV/AIDS in Canada. A descriptive, population-based economic evaluation study was conducted. Data from Statistics Canada were used, which contained information about aU men aged 25-64 years for whom HIV/AIDS or another selected disease was listed as the underlying cause of death from 1987 to 1991. Based on the human capital approach, the present value of future earnings lost for men was calculated. The estimated total loss from 1987 to 1991 was US 2.11 billion, with an average cost of US 558,000 per death associated with HIV/AIDS. Future production loss due to HIV/AIDS was more than double during the period 1987 to 1991, from US 0.27 to US 0.60 billion. A more comprehensive update of this smdy was presented by Hanvelt et al. (1996). The same database and the same data section but for the calendar years 1987-1993 was used. The indirect cost of future production due to HIV/AIDS in Canada based on the human capital approach for that period was estimated to be US 3.28 billion. The authors also calculated the willingness-to-pay to prevent premature death due to HIV/AIDS, which was estimated based on... 

The development of the differential equations which describe the evolution of particle size and molecular weight properties during the course of the polymerization is based on the so-called "population balance" approach, a quite general model framework which will be described shortly. Symbols which will be used in the subsections to follow are all defined in the nomenclature. 

To our knowledge, this is the first time that an emulsion copolymerization model has been developed based on a population balance approach. The resulting differential equations are more involved and complex than those of the homopolymer case. Lack of experimental literature data for the specific system VCM/VAc made it impossible to directly check the model s predictive powers, however, successful simulation of extreme cases and reasonable trends obtained in the model s predictions are convincing enough about the validity and usefulness of the mathematical model per se. 

Scope of the CLL approach. Critical loads and levels can be calculated for various specified sensitive elements of the environment (UNECE CLRTAP 2004, V-l). However, terrestrial and aquatic ecosystems are most frequently referred to as receptors in this effect-based approach. In addition, specific parts of ecosystems (e.g., populations of most valuable species) or ecosystem characteristics can be defined as receptors as well (UNECE CLRTAP, 2004). Such flexibility and established provisions for ecosystem assessment makes the CLL concept a promising solution for ecosystem risk assessment and a potential substitute for site-specific chemical RA following the bottom-up approach. 

Since NMR data may reflect the conformational averaging resulting from a substantial flexibility of DNA/RNA fragments, the parameters of the ensemble of structures obtained by MD refinement and experimental NMR restraints can display internal inconsistency. James and coworkers developed a method to determine the family of structural conform-ers and their populations based on NMR data [83]. This approach applies multiple-copy refinement with floating weights, which better reflects the conformational dynamics of nucleic acids. 

Several approaches have been proposed to deal with population stratification by using unlinked markers. In general, these methods fall into two categories model-based and non-model-based approaches. We briefly describe and explain three major methods and discuss their advantages as well as disadvantages. The basic understanding of these model-based and non-model-based methods is necessary and helpful when users apply them to analyze genetic data. 

Exploration of the scope of NPS in electrochemical science and engineering has so far been rather limited. The estimation of confidence intervals of population mean and median, permutation-based approaches and elementary explorations of trends and association involving metal deposition, corrosion inhibition, transition time in electrolytic metal deposition processes, current efficiency, etc.[8] provides a general framework for basic applications. Two-by-two contingency tables [9], and the analysis of variance via the NPS approach [10] illustrate two specific areas of potential interest to electrochemical process analysts. 

Ho vever this approach does not address inter-individual variability in CYP expression nor the apparent substrate specificity of RAFs. This may be overcome through the use of intersystem extrapolation factors (ISEFs) vhich compare the intrinsic activities of rCYP versus liver microsomes and provide CYP abundance scaling by mathematical means. This employs the RAF approach and adjusts for the actual amount of liver microsomes CYP present (measured by immunochemistry) rather than a theoretical amount (Equation 8.4). Such corrections can be made using nominal specific contents of individual CYP proteins in liver microsomes or more appropriately employ modeling and simulation software (e.g., SIMCYP www.simcyp.com) which takes into account population-based variability in CYP content. 

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