Molecular Recognition-Based Approach

By applying the principle of nucleic acid hybridization, a hydrogen-bond-mediated bilayer membrane can be designed from a pair of complementary molecular subunits 1, 2 (Figs. 4 and 5). When amphiphilic hydrogen bond pairs of alkylated chiral melamine (hydrophobic subunit 1) and quaternary ammonium - derivatized azobenzene cyanuric acid (hydrophilic subunit 2) were mixed in water, helical nanofibers (thicknesses 14-28 nm, widths 30-50 nm, pitches 180-430 nm) were immediately formed (Fig. 5, association constant 1.13 x 10 [37]. These helical nanofibers are typical of 

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It has been found that in two component systems zinc (II) porphyrin-ligand coordination properties of the metalloporphyrins increase in the following order ZnTPhPelectron effects of peripheral substitutes. In three component systems zinc (II) porphyrin-ligand-benzene the mentioned above properties change in the following order ZnPP>ZnDP>ZnHP>ZnTPhP and are inversely proportional to an ability of the macrocycle to 7r-7i-interactions with benzene. Thus, the new approach to molecular recognition based on specific salvation 71-71-interactions is demonstrated on example of znc (II) porphyrins. 

Removal of reversibly adsorbed (physisorbed) cyanine-dye molecules, D, led to skeletonized, SA silane monolayers having pinholes in the shape of D (Fig. 18) [185]. Such pinholes can, in turn, serve as templates for similarly shaped guest molecules. This approach opens the door for molecular recognition and device construction based on molecular recognition [186-190]. The idea relies upon the construction of a well-packed, SA monolayer from a mixture of OTS molecules and a solvent removable guest species. Removal of the guest molecules leaves pinholes with precise dimensions which only accept molecules with... 

This approach depends on the process of molecular recognition, which is based on the complementarity of the molecular shapes of the host and guest, and is shown schematically in Figure 1. 

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