High throughput based approach

Peptide catalysts, peptides that catalyze chemical reactions such as aldol, retro-aldol, and Michael reactions. In contrast to enzymes or catalytic antibodies ( abzymes), small peptides often display limited catalytic activity and substrate specificity. Combinatorial methods combined with reaction-based or catalysis-based high-throughput selection approaches are suited for catalyst optimization [E. Tanaka, Chem. Record 2005, 5, 276]. 

Palladium-based catalysts for enantioselective hydroamination reactions were discovered by extending the results of a high-throughput screening approach directed toward the discovery of non-selective hydroamination catalysts, reported by the Hartwig group in 2001. The approach taken by Hartwig and co-workers is described in Section 1.13.2.5. ... 

Wong, K. S., Kenseth, J., Strasburg, R. Validation and long-term assessment of an approach for the high throughput determination of lipophilidty (log Pow) values using multiplexed, absorbance-based capillary electrophoresis. J. Pharm. Sci. 2004, 93, 916-931. 

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