2 2 nanoparticle-based

For the preparation of nanoparticles based on two aqueous phases at room temperature one phase contains chitosan and poly(ethylene oxide) and the other contains sodium tripolyphosphate. The particle size (200-1000 nm) and zeta potential (between -i- 20 mV and -l- 60 mV) could be modulated by varying the ratio chitosan/PEO-PPO. These nanoparticles have great proteinloading capacity and provide continuous release of the entrapped protein (particularly insulin) for up to one week [100,101]. [Pg.161]

Heinze, T., Petzold, K. Hornig, S. (2007). Novel nanoparticles based on xylan. Cellulose Chemistry and Technology, Vol. 41,1, January 2007), pp. (13-18), ISSN 0576-9787... [Pg.81]

Wang J (2003) Nanoparticle-based electrochemical DNA detection. Anal Chim Acta 500 247-257... [Pg.348]

To prepare nanoparticles based on water-insoluble polymers, a solution of the polymer in an organic solvent can be emulsified within an aqueous phase. This O/W emulsion is then homogenized under high shear with an appropriate homogenization equipment... [Pg.274]

The rate of Au(III) reduction is also affected by ultrasound frequency as seen in Fig. 5.8. From TEM analyses, the size of the formed Au nanoparticles was found to be affected by ultrasound frequency. Figure 5.11 shows the relationship between the average size of the formed Au nanoparticles and the rate of Au(III) reduction. It is found that, even in the case of different frequency, the rate of Au(III) reduction affects the size of the formed Au nanoparticles. Based on the obtained results, the nucleation process is important in determining the size of Au particles, because the nucleation process should be closely related to the rate of reduction [29, 33],... [Pg.142]

Moritake S, Taira S, Sugiura Y, et al. Magnetic nanoparticle-based mass spectrometry for the detection of biomolecules in cultured cells. J. Nanosci. Nanotechnol. 2009 9 169-176. [Pg.388]

Biodegradable Nanoparticles as Vaccine Adjuvants and Delivery Systems Regulation of Immune Responses by Nanoparticle-Based Vaccine... [Pg.31]

Effect of Particle Size on Nanoparticle-Based Vaccines. 54... [Pg.32]

Fig. 12 Induction of immune responses by nanoparticle-based vaccine...

Regulation of Immune Responses by Nanoparticle-Based Vaccines... [Pg.53]

Kumari A, Yadav SK, Yadav SC (2009) Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surf B 75 1-18... [Pg.57]

Akagi T, Wang X, Uto T et al (2007) Protein direct delivery to dendritic cells using nanoparticles based on amphiphilic poly(amino acid) derivatives. Biomaterials 28 3427-3436... [Pg.59]

Park JH, Kwona S, Nam JO et al (2004) Self-assembled nanoparticles based on glycol chitosan bearing 5h-cholanic acid for RGD peptide delivery. J Control Release 95 579-588... [Pg.59]

Akagi T, Kaneko T, Kida T et al (2005) Preparation and characterization of biodegradable nanoparticles based on poly(y-glutamic acid) with L-phenylalanine as a protein carrier. J Control Release 108 226-236... [Pg.60]

Yoshikawa T, Okada N, Oda A et al (2008) Development of amphiphilic y-PGA-nanoparticle based tumor vaccine potential of the nanoparticulate cytosolic protein delivery carrier. Biochem Biophys Res Commun 366 408 -13... [Pg.63]

Akagi T, Higashi M, Kaneko T et al (2006) Hydrolytic and enzymatic degradation of nanoparticles based on amphiphilic poly(y-glutamic acidj-gra/t-L-phenylalanine copolymer. Biomacromolecules 7 297-303... [Pg.63]

The concept of de-PEGylation can be applied to the development of nanoparticle-based drug delivery systems. PEG is used for the modification of liposomes to increase their blood circulation time [38], However, it also prevents cellular uptake, resulting in a decrease in therapeutic efficiency thus, modifications of the liposome surface with PEG interfere with membrane fusion to the cell membrane and liposome decomposition [39]. One of the possible strategies to solve this problem is to cleave the PEG chains after the nanoparticle reaches the target site (Fig. 9). This system of de-PEGylation of liposomes is also useful in avoiding the immune... [Pg.123]

H. Wang, J.S. Li, Y.J. Ding, C.X. Lei, G.L. Shen, and R.Q. Yu, Novel immunoassay for Toxoplasma gondii-specific immunoglobulin G using a silica nanoparticle-based biomolecular immobilization method. Anal. Chim. Acta 501, 37-43 (2004). [Pg.278]

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