Targeting CD44-Expressing Tumours In Vivo with Hyaluronic Acid-based Nanoparticles

4 Targeting CD44-Expressing Tumours In Vivo with Hyaluronic Acid-based Nanoparticles 

1 Small Interfering Ribonucleic Acid and Chemotherapeutic Drugs as Therapeutic Agents 

HA MW (kDa) Radius of gyration (nm) Area (nm ) CD44 coverage (CD44 molecules available per HA) 

2 Choice of Tumour Models for Hyaluronic Acid-based Nanoparticle Delivery 

Jiang and co-workers also showed that the HA-PEI/siRNA complex accumulated mainly in tissues with high levels of HA receptors such as liver, kidney and tumour. Furthermore, they also showed that the intratumoural injection of anti-vascular endothelial growth factor targeted siRNA/HA-PEI complex resulted in effective inhibition of tumour growth by the GD44-mediated endocytosis to tumour cells in C57BL/6 mice [21]. 

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