53-cholanic acid

From the preceding data it can be seen that reduction studies with NaBH4 have not been as extensive as those with Li AIH4. Reduction at the 4-position of the 5a-H series should give a predominance of the -epimer. Reduction of a 2-keto-3j -acetoxy compound gives 84% of the 2, 3)5-diol. ° In the 5J -H series reduction of 7-ketocholanic acid gives a 75% yield of 7a-hydroxy-cholanic acid with only traces of the 7 -ol, but 7-ketocholesterol gives a mixture of the 7a- and 7j8-epimers. ... 

In the preparation of C-nor-D-homosteroid hormone analogs Mitsuhashi and Harada extended the Bamford-Stevens rearrangement to the cholanic acid series. Treatment of 3a-hydroxy-12-oxocholanic acid /j-toluene-... 

Fig. 2. Chemical structures of monensin (a) and cholanic acid (b). (Cited from Ref.8))...

Cholanic acid also possesses the ability of transporting cations across a lipophilic membrane but the selectivity is not observed because it contains no recognition sites for specific cations. In the basic region, monensin forms a lipophilic complex with Na+, which is the counter ion of the carboxylate, by taking a pseudo-cyclic structure based on the effective coordination of the polyether moiety. The lipophilic complex taken up in the liquid membrane is transferred to the active region by diffusion. In the acidic region, the sodium cation is released by the neutralization reaction. The cycle is completed by the reverse transport of the free carboxylic ionophore. 

Studies on the Antibacterial Properties of the Bile Acids and Some Compounds Derived from Cholanic Acid, M. Stacey and M. Webb, Proc. R. Soc., Ser. B, 134 (1947) 523-537. 

The 3,12-diacetoxy-wor-cholanic acid may be purified by crystallization from acetone. It melts at 207-208°. 

The solid crystalline cake (Note 2) is dissolved in about 400 ml. of ether and extracted with 500 ml. of 2.5% potassium hydroxide solution (Note 3). The alkaline solution is immediately acidified with 200 ml. of 10% hydrochloric acid, and the crude 3,12-diacetoxy-raor-cholanic acid (Note 4) is collected on a filter. 

Park JH, Kwona S, Nam JO et al (2004) Self-assembled nanoparticles based on glycol chitosan bearing 5h-cholanic acid for RGD peptide delivery. J Control Release 95 579-588... 

Cholanic acid C24H40O2, a monobasic saturated acid containing four hydroaromatic rings, is the parent substance of the two natural acids, which are its trihydroxy- and dihydroxy-derivatives. It is very highly probable that the following structural formula for cholic acid is correct ... 

Cholesterol C27H45OH, an unsaturated secondary alcohol, contains the same ring system as the bile acids and is closely related to them genetically. Pseudocholestane, indeed, which is a stereoisomer of the parent hydrocarbon of cholesterol, cholestane, can be oxidised to cholanic acid by chromic acid with elimination of acetone (Windaus). 

Conversely, pseudocholestane has also been obtained synthetically from cholanic acid. 

One of the ways in which cholesterol is catabolized in the organism is by its transformation into bile acids, the most important of which are cholic, deoxycholic, lithocholic, and cholanic acids. 

The most puzzling one was the Na salt of cholanate with = 277.0 K reported in 1976, though cholanic acid does not have 71-electrons (Scheme 17) [332]. The superconductivity was detected by conductivity and magnetic measurements. The authors mentioned that the salt showed an insulator to superconducting transition and the transition was fractional. Very recently, a biological compound (double-stranded DNA) was reported to exhibit proximity-induced superconductivity below 1 K [119]. The deionized DNA molecules are insulating and superconductivity cannot be expected. 

Abrus precatorius L. Siang Si Zi (Prayer beads) (seed) 1-Abrine, precatorine, hypaphorine, cycloarternol, squalene, trigonelline, 5-P-cholanic acid.33-450 Antiemetic, expectorant, parasiticide. 

Abrus precatorius L. China L-abrine, precatorine, squalene, hypaphorine, trigonelline, cycloarterenol, 5- 3-cholanic acid.33 Antiemetic, an expectorant, parasiticide. 

Two internal standards are used (5 / -cholanic acid, 3,12-diol-7-onc-5/3-cholanic acid) and dissolved in methanol at a concentration of 1 mg/ml. 

The method was first applied in studies of a bacterial polysaccharide, cholanic acid, composed of hexasaccharide repeating-units having117 the structure 51. The hydroxypropyl ester of this polysac-... 

ChIoro-5a-cholestane, 332 3/3-Chlorocholest-5-ene, 453 4-Chlorocyclohexanone, 72 3 /3-Chloro-5,6a-difluoro-5a-cholestane, 453 4-Chloro-17a-hydroxy-5/3-pregnane-3,11, 20-trione, 86 Chloroiridic acid, 101 4-Chloro-2-phenylquinazoline, 450 Choice of protecting groups, 375 A/B-cfs-cholanic acid, 228 Cholan-12-one, 36 Cholesta-3,5-diene, 207, 331, 336... 

Oxidation of 5/3-cholestane, but not 5a-cholestane, gave an acid that turned out to be identical with cholanic acid obtained by dehydration of cholic acid at 300° followed by hydrogenation ... 

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