Gelatin-based nanoparticles

Medical news today, Gelatin-Based Nanoparticle Effective In Gene Therapy For Breast Cancer, http //www.medicalnewstoday.com/articles/67880.php. 

A.O. Elzoghby, Gelatin-based nanoparticles as drug and gene dehvery systems reviewing three decades of research, Journal of Controhed Release 172 (2013) 1075-1091. 

Zillies, J. and C. Coester, Evaluating gelatin based nanoparticles as a carrier system for double stranded oligonucleotides. /. Pharm. Pharm. Sci., 7 (4) 17-21,2005. 

Allouche, J., Boissiere, M., Helary, C., Livage, J. and Coradin, T. (2006) Biomimetic core-shell gelatine/silica nanoparticles a new example of biopolymer-based nanocomposites. Journal of Materials Chemistry, 16, 3121-3131. 

Recently, chondroitin sulfate-cationized gelatin hybrid nanoparticles have been proposed for ocular gene therapy intended for topical administration. A plasmid codifying the mucin MUC5AC—essential for tear homeostasis but found at a decreased level in dry eye—was successfully transfected in vitro into cornea and conjunctiva cells [113,114]. Furthermore, these chondroitin sulfate-based nanoparticles were able to specifically transfect conjunctiva of rabbits and mice, as shown in Figure 8.6. In vitro cytoxidty and in vivo tolerance studies also showed that the system was innocuous under the conditions tested. 

Coester, C. (2003) Development of a new carrier system for oligonucleotides and plasmids based on gelatin nanoparticles. New Drugs 1 14-17. 

Li, J. K., Wang, N., and Wu, X. S. (1997), A novel biodegradable system based on gelatin nanoparticles and poly (lactic-co-glycolic acid) microspheres for protein and peptide drug delivery, J. Pharm. Sci., 86(8), 891-895. 

M.S. Sudheesh, S.P. Vyas, D.V. Kohh, Nanoparticle-based immunopotentiation via tetanus toxoid loaded gelatin and aminated gelatin nanoparhcles. Drug Dehvery 18 (2011) 320-330. 

G.K. Zorzi, J.E. Parraga, B. Seijo, A. Sdnchez, Hybrid nanoparticle design based on cat-ionized gelatin and the polyanions dextran sulfate and chondroitin sulfate for ocular gene therapy, Macromolecular Bioscience 11 (2011) 905-913. 

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