Delivery system

01 Iran (issue, which prevents this molecule from serving as an effective prodnig delivery form of S-fluorouracil. The iilhcruvo enzymes involved in the formation of S-fluoroura-cil occur in high concentrations in target tissues such as cervix, breast, kidney, and colon. 

CNS via pa.ssivc ub.sorption of the icniury amine, which on oxidation restricts the resulting pyridinium amide to the brain. Amide hydrolysis then delivers the active fomi of the drug at or near its site of action. The amide hydrolysis step may be slower than the dihydropyridine oxidation step, and thus a reservoir of pyridinium amide precursor may be available for conversion to the active drug species. 

Chemistry of Drug Design and Drug Action New York. Acudeinic Press, 1992. Chap. 8. pp.. 1.52-401. 

Remers. W. A. Milomycin and porfiromyctn. In The Chettiivlr ot Antitumor Aniibtolicv New York. Wiley. 1979. pp. 221-276. 

Continuous minipumps have been developed which can release insulin at varying rates depending on blood-glucose levels. This appears to be the best answer to the problem of providing insulin at the correct levels at the correct times. 

Some acid-sensitive drugs can be protected by the way they are formulated. For example, it is possible to coat pills with an acid-resistant polymer which protects the drug from the acids in the stomach. The polymer is designed to be removed under the slightly alkaline conditions of the large intestine. Unfortunately, absorption in the large intestine is not so efficient as the small intestine and so the applications are limited. 

A physical way of protecting drugs from metabolic enzymes in the bloodstream is to inject small vesicles called liposomes filled with the drug. These vesicles or globules consist of a bilayer of fatty molecules in the same way as a cell membrane and will travel round the circulation, slowly leaking their contents. 

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Course Management Systems— PageOut WebCT and Blackboard All of the following tools are available on the Online Learning Center or m a cartridge for your course delivery system... 

Raman spectraof [INFRARED TECHNOLOGY AND RAMAN SPECTROSCOPY - RAMAN SPECTROSCOPY] (Voll4) -role in drug delivery pRUG DELIVERY SYSTEMS] (Vol 8)... 

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