Drug Delivery Systems Based on Pillararenes and Mesoporous Silica Nanoparticles

2 Drug Delivery Systems Based on Pillararenes and Mesoporous Silica Nanoparticles 

In order to investigate the cargo loading and controlled release of CP[5]A-hybridized MSNs, rhodamine B (RhB) has been encased in MCM-41 nanoparticles, and CP[5]As have been used to encircle the terminals of the stalks. According to the UV-vis absorption spectra, RhB will be trapped and loaded in the pores of the MSNs and will not leak out, owing to the steric hindrance of CP[5]As when the system is under neutral or basic conditions. The flat baseline shows that there is negligible premature release. However, upon 

Used with permission from ref. 52. Copyright 2013 Wiley. 

Subsequently, Huang and Du have reported a carboxylate-substituted pillar[6]arene-valved MSN, which was used for stimuli-responsive drug delivery. The release of cargo was triggered by acidic pH or competitive binding agents. 

In addition, our group have fabricated another type of pillar[5,6]arene-based material, hybridized with silicon dioxide. The perhydro3q l-pillar[5]-arene and perhydro y l-pillar[6]arene were attached onto the hydrophilic silica supports through covalent bonds. This pillar[n]arene-based composite can act as an absorbent hybrid material for some typical herbicides. 

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