Chitosan Based Functionalized Nanoparticles

Functionalization and derivatization of chitosan is known to be the most reliable alternative for modifying its physico-chemical and biological properties. Recently N,N,N-trimethyl chitosan nanoparticles has explored as a vitamin carrier system whereas N-Acylated chitosan stabilized iron oxide nanoparticles has proven as a novel nano-matrix for ceramic modification [120, 121]. Similarly various other 

Chitosan based self assembled/amphiphilic NPs plays a vital role in delivery of number of drugs, nucleic acids and metals. Recently, the effects of hydrophobic and hydrophilic modifications on gene delivery of amphiphilic chitosan based nanocarriers investigated and it has been observed that this type of modification allowed the improved gene delivery via amphiphilic nanoparticles [128]. It was reported that the chitosan-based self-assembled nanoparticles can be readily obtained by chemically attaching the hydrophobic moiety to the backbone of chitosan and its derivatives, as shown in Fig. 3.5. These self-assembled nanoparticles can circulate in the 

Li et al. explored novel amphiphilic oleoyl-carboxymethyl chitosan self-assanbled nanoparticles [147]. Morris et al., investigated the effect of prolonged storage at different temperatures on the particle size distribution of tripolyphosphate (TPP) -chitosan nanoparticles and it was observed that fabricated nanoparticles showed uniform particle size distribution [129]. In one study, novel MPEG-chitosan diblock copolymer and self-assembly of nanoparticles were explored [148]. In another study self-assembled nanoparticles of 6-0-cholesterol-modified chitosan for drug delivery were fabricated [149]. These nanoparticles were reported for their improved delivery. 

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Functionalized Nanoparticles and Chitosan-Based Functional Nanomaterials... 

Fig. 1 Preparation of chitosan-based functional nanomaterials, (a) Preparation of quantum dot (QD). (b) Chitosan-GNP derivative, (c) Fullerene-based cbitosan derivative [198]. (d) Immobilization of gold nanoparticles onto tbiol-functionalized cbitosans...

This section emphasizes recent research on different aspects of chitosan-based functional nanomaterials, including applications of chitosan-based functional metal nanoparticles (gold, iron oxide, and silica), carbon-based nanomaterials (CNTs, graphene and fullerene), quantum dots, and liposomes for tissue engineering, wound dressing, drug delivery, cancer diagnosis, and some industrial applications. 

A. Di Martino, and V. Sedlarik, Amphiphilic chitosan-grafted-functionalized polylactic acid based nanoparticles as a delivery system for doxorubicin and temozolomide cotherapy, Int. J. Pharm., 474 (1-2), 134-145, 2014. 

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