Nanoparticle-based carriers

Akagi T, Kaneko T, Kida T et al (2005) Preparation and characterization of biodegradable nanoparticles based on poly(y-glutamic acid) with L-phenylalanine as a protein carrier. J Control Release 108 226-236... 

Yoshikawa T, Okada N, Oda A et al (2008) Development of amphiphilic y-PGA-nanoparticle based tumor vaccine potential of the nanoparticulate cytosolic protein delivery carrier. Biochem Biophys Res Commun 366 408 -13... 

A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drag molecules. 

Particulates are commonly classified into micro- and nanoparticles based on the size of the particles. Nanoparticles are colloidal particles ranging from 10 to 1,000 run, in which drag may be entrapped, encapsulated, and/or absorbed. Microparticulates are drag-containing small polymeric particles (erodible, non-erodible or ion-exchange resins) within the size of 1-10 /on, which are suspended in a liquid carrier medium. 

A novel nanoparticulate lipid-based carrier system was developed by Mumper et al. at the University of Kentucky. ° This carrier system is composed of a lipophilic-emulsifying wax such as cetyl alcohol/ polysorbate 60 and other surfactants such as Brij 72, Brij 78, and Tween 80. The nanoparticles were formed through a warm microemulsion technique where encapsulates have included paclitaxel and plasmid DNA. The emulsification process is spontaneous, and cooling of the emulsion causes solidification of the nanoparticle-containing drug. This novel carrier has shown high efficiency in drug delivery across the blood-brain barrier. 

Hyung Park J, Kwon S, Lee M (2006). Self-assembled nanoparticles based on glycol chitosan bearing hydrophobic moieties as carriers for doxorubicin In vivo biodistribution and anti-tumor activity. Biomaterials. 27 119-126. 

FIGURE 25.6 Different approaches which have been developed for protection of chitosan-based carriers loaded with antigen from harsh environment of stomach (A) protected alginate coated chitosan nanoparticles (B) encapsulation of chitosan nanoparticles within vesicular systems. 

S. Y., A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules. Journal of the American Chemical Society 125, (15), 4451 59, 2003. 

Zhang J, Chen XG, Li YY et al (2007) Self-assembled nanoparticles based on hydrophobically modified chitosan as carriers for doxorubicin. Nanomedicine 3 258-265... 

Due to their positive influence on skin hydration and viscoelasticity ° ° as well as their UV-blocking potential, solid lipid nanoparticles and the related nanostructured lipid carriers appear very promising for cosmetics and first cosmetics based on SEN are commercial available. Eipid nanoparticle based formulations were e.g. developed for anti-ageing and sunscreen formulations. As cosmetics shall be active solely on the skin, the permeation of components of the formulations through the skin is undesirable because of potential adverse systemic effects. 

Nanoparticles based on the supercooled smectic phase of cholesterol esters were introduced as a potential novel carrier system for lipophilic drugs. Due to the high viscosity of the smectic phase but mobility on the molecular level, advantages in... 

Wu ZL, Shi G, Ni C. Zwitterionic pH/redox nanoparticles based on dextran as drug carriers for enhancing tumor intercellular uptake of doxorubicin. Mater Sci Eng C. 2016 61 278-85. 

Diomsio M, Cordeiro C, Remunan-Lopez C, Seijo B, Rosa CAM, Grenha A. Pullulan-based nanoparticles as carriers for transmucosal protein delivery. Eur J Pharm Sd. 2013 ... 

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