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Vaccines, nanoparticle-based

Biodegradable Nanoparticles as Vaccine Adjuvants and Delivery Systems Regulation of Immune Responses by Nanoparticle-Based Vaccine... [Pg.31]

Effect of Particle Size on Nanoparticle-Based Vaccines. 54... [Pg.32]

Fig. 12 Induction of immune responses by nanoparticle-based vaccine... Fig. 12 Induction of immune responses by nanoparticle-based vaccine...
Regulation of Immune Responses by Nanoparticle-Based Vaccines... [Pg.53]

Yoshikawa T, Okada N, Oda A et al (2008) Development of amphiphilic y-PGA-nanoparticle based tumor vaccine potential of the nanoparticulate cytosolic protein delivery carrier. Biochem Biophys Res Commun 366 408 -13... [Pg.63]

As of today, there are no commercially available pharmaceutical products of this technology. The pharmaceutical industry however, is involved in developing nanoparticle-based delivery systems. Use of nanospheres to modify the blood-brain barrier (BBB)—limiting characteristics of the drug enables targeted brain delivery via BBB transporters and provides a sustained release in brain tissue and vaccine delivery systems to deliver therapeutic protein antigens into the potent immune cells are under investigation.103... [Pg.297]

However, being a natural polymer, chitosan has aU disadvantages of natural materials mentioned earlier (see Section 11. A). Presently, a lot of other polyplexes based on cationic synthetic polymers have been described in the literature. Among others, we could mention rather new DNA delivery nanoparticles based on poly(2-dimethylamino)ethyl methacrylate-co-poly(ethylene glycol) (PDMAEMA) [70,71] and PEGylated polyethylenimine (PEI/DNA) [72]. The last polyplexes have been encapsulated in PLGA microparticles and proposed for mucosal (oral) polyplex-based vaccination of Wistar rats. [Pg.863]

The interstitial fluid content of the skin is higher than in the subcutaneous fat layer and normal fluid movement is intrinsically finked to lymphatic drainage as governed by mechanical stresses of the tissue. A model of temporal profiles of pressure, stress, and convective ISF velocity has been developed based on hydraulic conductivity, overall fluid drainage (lymphatic function and capillary absorption), and elasticity of the tissue.34 Measurements on excised tissue and in vivo measurement on the one-dimensional rat tail have defined bulk average values for key parameters of the model and the hydration dependence of the hydraulic flow conductivity. Numerous in vivo characterization studies with nanoparticles and vaccines are currently underway, so a more detailed understanding of the interstitial/lymphatic system will likely be forthcoming. [Pg.194]

Garinot, M., V. Fievez, et al. (2007). PEGylated PLGA-based nanoparticles targeting M cells for oral vaccination. J Control Release 120(3) 195-204. [Pg.165]

Chu, B. Y., Kobaisi, M. A., Zeng, W., Mainwaring, D., Jackson, D. C. (2011). Chitosan microparticles and nanoparticles as biocompatible delivery vehicles for peptide and protein-based immunocontraceptive vaccines, Mol. Pharm.. 9(1), 81-90. [Pg.575]

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