Phytochemicals Based Chitosan Nanoparticles

Natural products carry enormous therapeutic potential with considerable safety. Chitosan has been recently used for delivery of various phytochemicals. Various forms of chitosan based drug delivery systems have been explored in which chitosan act as carrier and phytochemicals act as model drug. These carrier and model drugs are often utilized in form of nanoparticles for cell, tissue or organ specific dehvery. Various examples of other phytochemicals and their applications are mentioned in Table 3.9. 

26 Glycosylated Chitosan Nanoparticles siRNA Chitosan Conjugate 

Chitosan/siRNA NPs have profound application in gene silencing, especially in cancer/mahgnant disorders. Holzemy et al. investigated the biophysical properties of chitosan/siRNA polyplexes. In this study he has demonstrated the profiling the polymer/siRNA interactions and its bioactivity [283], Various applications of chitosan/siRNA nanoparticle are highlighted in Table 3.10 

Water soluble 0-carboxymethyl chitosan nanocarrier For the delivery of curcumin to cancer cells [273] 

Carboxymethyl chitosan carrying ricinoleic NPs As an emulsifier for azadirachtin [274] 

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