Myocardial infarcts

There have been many sporadic reports that lipo-PGEj is effective in fulminant hepatitis, neuralgia associated with herpes zoster, multiple spinal canal stenosis, cerebral infarction, myocardial infarction, chronic renal failure, and bed sores as well as for its registered indications. 

Siminiak T, Fiszer D, Jerzykowska O, Grygielska B, Rozwadowska N, Kalmucki P, Kurpisz M. Percutaneous trans-coronary-venous transplantation of autologous skeletal myoblasts in the treatment of post-infarction myocardial contractility impairment the POZNAN trial. Eur i/eart / 2005 26 1188-1195. 

Jang IK, Brown DFM, Giugliano RR et al, A multicenter, randomized study of argatroban versus heparin as adjunc to tissue plasminogen activator (TPA) in acute myocardial infarction myocardial infarction with Novastan and TPA (MINT) study. J Am Coll Cardiol I 999 33 1 879-1885. 

Itoh G, Tamura J, Suzuki M, Suzuki Y, Ikeda H, Koike M, et al. DNA fragmentation of human infarcted myocardial cells demonstrated by the nick end labeling method and DNA agarose gel electrophoresis. Am J Pathol 1995 146 1325-1331. 

Biological Applications Calcium indicatois zinc indicators treating acute cell death, cerebral infarction, myocardial infarction, hepatonecrosis, kidney ischemic necrosis, necrotizing pancreatitis, amyloidosis, atherosclerosis, diseases characterized by calcification and/or plaque formation, osteoporosis, Paget s disease, heterotropic ossification, hypercalce-mia, cancer, inflammation, diabetes mellitus, epilepsy, epithelial disorders, glaucoma, HIV-associated conditions, respiratory disorders, streptococcal infection, viral diseases ... 

Congestive heart failure (CHF) due to ischemic heart disease is a very common clinical situation, particularly in the elderly group of patients. It is however unclear how the myocardial cells behave metabolically when decreased blood flow in the myocardial tissue develops as a result of stenosis, or obstruction of coronary vessels, eventually leading to myocardial infarction. Myocardial metabolism was studied by microcalorimetry and oxygen consumption measurement in tissue from rats with CHF after a myocardial infarction, induced by ligation of the left coronary artery [89]. 

However, it has been shown that both coronary artery disease and the platelet and coagulation systems in swine are very similar to those in hunums, and that the clinical syndromes of sudden death and acute myocardial infarction appear to be comparable [63, 64, 122]. Recently, it was demonstrated that after dietary supplementation with cod-liver oil severely hyperlipidemic swine exhibit retarded atherosclerotic disease development, with no relation to changes in plasma lipids, but associated with changes in the arachidonate and eicosapentaenoic acid content of platelet membranes [123]. Moreover, cats fed with menhaden oil showed significantly smaller neurological deficits after ligation of the left middle cerebral artery [13], and dogs fed with cod-liver oil exhibited smaller sizes of infarcted myocardial tissue than controls after electrical stimulation of the left circumflex coronary artery [22]. 

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