Acute myocardial infarction peptide

Hay, D.L. and Smith, D.M., Adrenomedullin receptors molecular identity and function. Peptides 22, 1753-1763, 2001 Julian, M., Cacho, M., Garcia, M.A. et al., Adrenomedullin a new target for the design of small molecule modulators with promising pharmacological activities, Eur. J. Med. Chem. 40,737-750,2005 Shimosawa, T. and Fujita, T., AdrenomeduUin and its related peptides, Endocr. J. 52,1-10, 2005 Zudaire, E., Portal-Nunez, S., and Cuttitta, F., The central role of adrenomedullin in host defense, J. Leak. Biol. 80, 237-244, 2006 Hamid, S.A. and Baxter, G.F, A critical cytoprotec-tive role of endogenous adrenomedullin in acute myocardial infarction, J. Mol. Cell Cardiol. 41, 360-363, 2006. 

Protein manipulation for enzyme proteins can serve as a good example of several possible manipulations. Alteplase is a thrombolysis enzyme protein used to prevent death in acute myocardial infarction. The protein has 527 amino acids, 5 disulfide bridges, glycosylation at several amino acids, and 5 peptide domains. Truncation of most domains leaving intact the protease domain resulted in a new biological, reteplase (Retevase), with quite similar thrombolytic activity. Another set of... 

Omland T, Aakvaag A, Bonarjee W, Caidahl K, Lie RT, NUsen DW, et al. Plasma brain natriuretic peptide as an indicator of left ventricular systolic function and long term survival after acute myocardial infarction. Circulation 1996 93 1963-9. 

Bassan R, Potsch A, Maisel A et al. B-type natriuretic peptide a novel early blood marker of acute myocardial infarction in patients with chest pain and no ST-segment elevation. Eur Heart J 2005 26 234. 

Nikolaidis LA, Mankad S, Sokos GG, Miske G, Shah A, Elahi D, et al. Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 2004 109 962-965. [Epub 2004 Feb 23.]... 

Jensen, L.T., Horslev-Petersen, K., Toft, P. et al.. Serum aminoterminal type III procoUagen peptide reflects repair after acute myocardial infarction. Circulation, 81,52-57,1990. 

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