Acute myocardial infarction myoglobin

Myoglobin levels determined in normal serum and elevated levels in patients with acute myocardial infarction... 

ENI6 Collins, R. and Tucker, J. (1991). Myoglobin and CK-MB tests for the diagnosis of acute myocardial infarction in emergency room patients. Clin. Chem. 37, 978, Abstr. 322. 

Figure 44-23 Clinical sensitivities (with 95% confidence limits) of creatine kinase-2 (CK-MB), myoglobin, and troponins I and T (cTr-l, cTr-T) for AM as a function of time from presentation at the emergency department (ED). (Data from Tucker JF, Collins RA, Anderson Aj, Houser j, Kalas j, Apple FS. Early diagnostic efficiency of cardiac troponin I and cardiac troponin T for acute myocardial infarction. Acad Emerg Med 1997 4 13-21.)...

Figure 44-24 ROC curves for A cTnT, CK-MB, and myoglobin and B CK-MB and cTnl for diagnosis of acute myocardial infarction, according to sample time from admission (0 hours).

Figure 44-30 Time course (mean and standard error) of serum cardiac troponin (cTnl), cardiac troponin T (cTnT), creatine kinase-2 (CK-MB), and myoglobin (MYO) concentrations after initiation of thrombolytic therapy in patients withTIMi Grade 3 reperfusion flow. (From Apple FS, Sharkey SVV Henry TD. Early serum cardiac troponin I and T concentrations following successful thrombolysis for acute myocardial infarction, Clin Chem I995 4I 1197-8.)...

Apple FS, Voss E, Lund L, Preese L, Berger CR, Henry TD. Cardiac troponin, CK-2, and myoglobin for the early detection of acute myocardial infarction and... 

Gibler WB, Gibler CD, Weinshenker E, Abbottsmith C, Hedges JR, Barsan WG, et al. Myoglobin as an early indicator of acute myocardial infarction. Ann Emerg Med 1987 16 851-6. 

McCord J, Nowak RM, McCullough PA, Foreback C, Borzak S, Tokarski G, et al. Ninety minute exclusion of acute myocardial infarction by use of quantitative point-of-care testing of myoglobin and troponin I. Circulation 2001 104 1483-8. 

Vaananen HK, Syrjala H, Rahkila P, Vuori J, Melamies LM, MyUyla V, et al. Serum carbonic anhydrase III and myoglobin concentrations in acute myocardial infarction. Chn Chem 1990 36 635-8. 

Anne Jeina. Mrs. Jeina s diagnosis of an acute myocardial infarction J (MI) was based partly on measurements of CK-MB, myoglobin, and cTN- T (the cardiac isozyme of troponin-T, a subunit of the regulatory protein... 

In the acute setting of cocaine-induced chest pain, assessment includes the possible diagnosis of acute myocardial infarction. However, cocaine may independently affect cardiac biomarkers [22 ]. Recent cocaine use may alter the specificity of measurement of serum creatine kinase and its MB Iraction. Among cocaine users, increased serum creatine kinase activities and increased mean myoglobin concentrations are common. Increased skeletal muscle activity and rhab-domyolysis are often present, possibly because of cocaine-induced hyperthermia. Troponin I concentrations are more reliable cardiac biomarkers for detecting cocaine-induced myocardial infarction and are associated with a poor prognosis. 

Cardiac myoglobin detection was based on direct electron transfer between the Fe(III)-heme and the electrode surface that was modified with metal nanoparticles stabilized by didodecyldimethylammonium bromide and antibodies. Gold, silver, and copper nanoparticles were tested as catalysts of the Fe(III)/Fe(II) electrode process. Experiments were carried out with human blood plasma samples of healthy donors and patients with acute myocardial infarction. The method proposed does not require labeled secondary antibodies. The myoglobin immunosensor has a detection limit of 5 ngrnL and a broad range of working concentrations (Suprun et al., 2011). The whole procedure takes 20 min and can be used to establish the diagnosis of acute myocardial infarction. 

Grenadier E, Keidar S, Kahana L, Alpan G, Marmur A, Palant A. The roles of serum myoglobin, total CK, and CK-2 isoenzymes in the acute phase of myocardial infarction. Am Heart J 1983 10 408-16. 

In the emergency room, the physician had drawn blood for the measurement of myoglobin, CK-MB (creatine kinase, muscle-brain fraction) and cTN-T (cardiac troponin T subunit). The results from these tests had supported the diagnosis of an acute MI (myocardial infarction), and Mrs. Jeina was hospitalized. 

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