Myocardial infarcts imaging agents

MyoScint (Imiciromab-Pentetate murine mAb fragment directed against human cardiac myosin) Centocor myocardial infarction imaging agent 1996 (US)... 

Structures of Diphosphonate Complexes. Diphosphonate ligands are widely used to prepare Tc-99m skeletal imaging agents and Tc-99m myocardial infarct imaging agents (1,2). The constitutions, and associated acronyms, of several diphosphonates are shown below along with that of the related ligand pyrophosphate ... 

These structural studies emphasize the central role of polymeric metal-diphosphonate complexes in the chemistry of technetium-diphos-phonate calcium seekii agents. It is clearly the ability of diphosphonates to bridge metal centers that provides the mechanism for the initial sorption of the radiopharmaceutical onto bone. Mixed metal (technetium, tin, and calcium) diphosphonate polymeric complexes are likely to be the dominant chemical species in clinically used skeletal and myocardial infarct imaging events. An understanding of the chemistry of these polymeric species will be crucial to an understanding of the mechanisms of action of diphosphonate radiopharmaceuticals and to the development of more efficacious imaging scents. 

Kits containing tin-pyrophosphate as a sterile, nonpyrogenic formulation are either reconstituted with sterile saline or with sterile sodium Tc-pertechnetate solution. 99mrpc-pYp jjas been used for imaging myocardial infarction the cold kits serve as stannous agent for in vivo labeling of RBC. No bacteriostatic preservative is present in kits. 

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