Opioid analgesics myocardial infarction

Morphine is an opioid analgesic that may be used for pain relief in myocardial infarction. However, diamorphine is usually preferred because it causes a lower risk of nausea and hypotension than morphine. 

Acute pain is the presence of severe discomfort or an uncomfortable sensation that has a sudden onset and subsides with treatment. For example, a fractured bone causes acute pain since the uncomfortable sensation occurs suddenly when the bone is broken and subsides when the bone is immobilized in a cast. Pain associated with myocardial infarction (heart attack), appendicitis, and kidney stones are also examples of acute pain. Acute pain can be treated with NSAIDs or opioid analgesics. 

Visceral pain is the dull and aching pain caused by stimulating nerve endings in smooth muscle or sympathetically innervated organs. Visceral pain is referred pain. This makes it difficult to localize the source of the pain. Pain of a myocardial infarction (MI) is an example of visceral pain. MI can be described as cmshing chest pain and also described as pain in the left arm or hand and even the shoulder, left back, or the left ear. Visceral pain is best treated with opioid analgesics. 

An established interaction although information is limited. The delay and reduction in the absorption would seem to limit the value of oral mexiletine during the first few hours after a myocardial infarction, particularly if opioid analgesics are used. The manufacturer suggests that a higher load-... 

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