Myocardial infarction, hyaluronidase

M. de uiiveira, R. Carbaiio, and H. A. Zimmetman. intravenous injection of hyaluronidase in acute myocardial infarction preliminary report of clinical and experimental obsmvatinns. Am- Heart J. 57 712(1959). 

I. Rep a, J. D. Gamic, and N. K. Holknberg. Myocardial infarction treated with two lymphagogues, calcium dobesilate (CLS 221(0 snd hyaluronidase a coded,... 

S.Saldssl,D.J. Collart, P. S.Robinson,M. M. Webb-Feploe,andD.N.Croft. Effects of early administration of a highly purified hyaluronidase preparation (GL enzyme) on myocardial infarct size. Lancer 17 867 (1962). 

The first reports on the beneficial effects of hyaluronidase in the treatment of acute myocardial infarction were published by de Oliveira et al. [99]. Hyaluronidase was administered intravenously to dogs in which infarction was... 

D. Maclean, M. C. Fishbein, P. R. Maroko, and E. Braunwald. Hyaluronidase-induced reductions in myocardial infarct size. Science 194 199 (1976). 

J. E. Nilsson, C. Sjogren, and U. Sawe. The effects of a highly purified hyaluronidase preparation on experimental myocardial infarction in the rat. Acta Med. Scand. 276 209 (1984). 

E. J. Flint, P. J. Cadigan, J. De Giovanni, and P. Lambi. Effect of GL enzyme (a highly purified form of hyaluronidase) on mortality after myocardial infarction. Lancet 77 871 (1982). 

M1LIS study group. Hyaluronidase therapy for acute myocardial infarction results of a randomized, blinded, multicenter trial. Am. J. Cardiol. 57 1236 (1986). 

The major clinical use of hyaluronidase is in ophthalmology, by improving the local anesthetic infiltration [128, 129], The anesthetic-hyaluronidase combinations has also found applications in pain relief for high ligations in varicose vein surgery or hernia surgery [130], Clinically, the enzyme is used in chemotherapy to enhance the antineoplastic activity of cytostatics and in the treatment of acute myocardial infarction [131],... 

---