Superoxide dismutases myocardial infarction

Plasma malondialdehyde-like material, an indicator of lipid peroxidation, is increased in conditions of ischaemia, such as stroke [83, 84] and myocardial infarction [85]. Mitochondria extracted from hearts of vitamin-E-deficient rabbits showed a decreased mitochondrial function and an increased formation of oxygen radicals associated with a reduced superoxide dismutase activity. This was partially reversed by addition of vitamin E in vitro [86]. Measurement of in vitro susceptibility to lipid peroxidation in cardiac muscle from vitamin-E-deficient mice showed a highly significant negative correlation between the concentration of vitamin E and in vitro lipid peroxidation. The results indicate that short-term vitamin E deficiency may expose cardiac muscle to peroxidation injuries [ 87 ]. In rats, treatment for 2 days with isoprenaline increased lipid peroxide activity, as measured by malondialdehyde levels, in the myocardium. Vitamin-E-deficient animals were even more sensitive to this effect, and pretreatment with a-tocopheryl acetate for 2 weeks prevented the effect induced by isoprenaline. The authors [88] propose that free-radical-mediated increases in lipid peroxide activity may have a role in catecholamine-induced heart disease. 

Li Q, Bolli R, Qiu Y Tang X-L, Guo Y French BA. Gene therapy with extracellular superoxide dismutase protects conscious rabbits against myocardial infarction. Circulation 2001 103 1893-1898. 

T. Miura, J.M. Downey, D. Hotta and O. Iimura, Effect of superoxide dismutase plus catalase on myocardial infarct size in rabbits, Can. J. Cardiol. 4(8), 407-411 (1988). 

K5. Kawaguchi, T., Suzuki, K., Matsuda, Y., Nishiura, T., Uda, T., Ono, M., Sekiya, C., Ishikawa, M., lino, S., Endo, Y., and Taniguchi, N., Serum Mn-superoxide dismutase Normal values and increased levels in patients with acute myocardial infarction and several malignant diseases determined by enzyme-linked immunosorbent assay using a monoclonal antibody. J. Immunol. Methods 127, 249-254 (1990). 

Ul. Uraizee, A., Reimer, K. A., Murry, C. E., and Jennings, R. B., Failure of superoxide dismutase to limit size of myocardial infarction after 40 minutes of ischemia and 4 days of reperfusion in dogs. Circulation 75, 1237-1248 (1987). 

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