Donors acute myocardial infarction

Potential cardiovascular therapeutic uses for PFC emulsions, other than CPB, include treatment of acute myocardial infarction, cardioplegia, reperfusion, coronary angioplasty and preservation of donor hearts for transplantation. High 02-delivery capacity, small particle sizes, and low viscosity may improve tissue perfusion and oxygenation. Treatment of cardiac arrest is also being explored. 

Cardiac myoglobin detection was based on direct electron transfer between the Fe(III)-heme and the electrode surface that was modified with metal nanoparticles stabilized by didodecyldimethylammonium bromide and antibodies. Gold, silver, and copper nanoparticles were tested as catalysts of the Fe(III)/Fe(II) electrode process. Experiments were carried out with human blood plasma samples of healthy donors and patients with acute myocardial infarction. The method proposed does not require labeled secondary antibodies. The myoglobin immunosensor has a detection limit of 5 ngrnL and a broad range of working concentrations (Suprun et al., 2011). The whole procedure takes 20 min and can be used to establish the diagnosis of acute myocardial infarction. 

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