Myocardial Infarction Registry

Obstacles remained as PTCA was not universally available and often associated with considerable time delay, especially in off peak hours. In the National Registry of Myocardial Infarction-2 (NRMI-2 >27,000 patients), total ischemia time (symptom onset to balloon inflation) was 3.9 h with onset to hospital arrival 1.6 h [45]. Unadjusted in-hospital mortality was higher in patients treated later. Door to balloon time > 2 h was related to in-hospital death (41-62% adjusted odds increase) and centers who treat >3 STEMIs/month had improved in-hospital mortality compared to less experienced facilities (Figs. 5.4 and 5.5). Lastly, similar to trials of unstable angina, PTCA was plagued by high restenosis rates... 

Barron HV, Every NR, Parsons LS, et al. The use of intra-aortic balloon counterpulsation in patients with cardiogenic shock complicating acute myocardial infarction data from the National Registry of Myocardial Infarction 2. Am Heart J 2001 141 933-939. 

Collinson J, Flather MO, Fox KA et al. Clinical outcomes, risk stratification and practice patterns of unstable angina and myocardial infarction without ST elevation Prospective Registry of Acute Ischaemic Syndromes in the UK (PRAIS-UK). Eur Heart J 2000 21 1450. 

Curtis JP, Portnay EL, Wang Y et al. National Registry of Myocardial Infarction-4. The pre-hospital electrocardiogram and time to reperfusion in patients with acute myocardial infarction, 2000-2002 findings from the National Registry of Myocardial Infarction-4. J Am Coll Cardiol 2006 47(8) 1544. 

Roe MT, Parsons LS, Pollack CV, Jr, et al. National Registry of Myocardial Infarction Investigators. Quality of care by classification of myocardial infarction treatment patterns for ST-segment elevation vs non-ST-segment elevation myocardial infarction. Arch Intern Med 2005 165 1630-6. 

Wiviott SD, Morrow DA, Frederick PD, Antman EM, Braun-wald E National Registry of Myocardial Infarction. Application of the thrombolysis in myocardial infarction risk index in non-ST-segment elevation myocardial infarction evaluation of patients in the National Registry of Myocardial Infarction. J Am Coll Cardiol 2006 47(8) 1553. 

MIAMI Metoprolol In Acute Myocardial Infarction NRMI National Registry of Myocardial Infarction NTG nitroglycerin... 

Spencer FA, Meyer TE, Gore JM, Goldenberg RJ. Heterogeneity in the management and outcomes of patients with acute myocardial infarction complicated by heart failure The National Registry of Myocardial Infarction. Circulation 2002 105 2605-2610. 

The AMADEUS registry is a prospective multicenter European registry to evaluate the safety and efficacy of the CARILLON Mitral Contour System in patients with function mitral regurgitation. Joachim Schofer recently presented 6-month clinical outcomes of 48 patients (34). Among the 30 patients with successful device placement, cardiac perforation was noted in three patients at one month and there were two deaths (6.9%) and three myocardial infarctions reported at six months. The regurgitant volume was reduced from 35 16 mL at baseline to 24 12 at six months (P <0.001) and six-minute walk test increased from a mean of 307 meters to 403 meters (P <0.001). 

Acute infarct artery PCI was demonstrated initially to be feasible in conjunction with intracoronary thrombolysis in a small registry study reported in 1982 (43). The approach evolved quickly to one in which the intracoronary thrombolysis component was abandoned. The separation of mechanical and pharmacological approaches was reinforced by results in a small (56-patient), but very influential, randomized trial comparing primary PCI with administration of intracoronary streptokinase in 1986 (44). Primary PCI led to greater recovery of left ventricular function. Results from another relatively small, randomized trial (n = 142) were concordant. They demonstrated greater recovery of left ventricular function with primary PCI compared with intravenous streptokinase (45). The Primary Angioplasty in Myocardial Infarction... 

Figure 1.3 A contrast between the induction of rapid recanaiizadon in ciin-ical practice with primary PCI (National Registry of Myocardial Infarction, NRMI) compared with results in recent randomized clinical trials of Primary PCI (DANAMI-2). The median time to coronary opening for on-site and transfer patients is snbstantiaUy less in the trial compared with that seen in clinical practice, particnlarly when transfer is required. (From Refs. 59,60,71.)...

Tiefenbrunn AJ, Chandra NC, French WJ, Gore JM, Rogers WJ. Clinical experience with primary percutaneous transluminal coronary angioplasty compared with alteplase (recombinant tissue-type plasminogen activator) in patients with acute myocardial infarction a rqx)rt from the Second National Registry of Myocardial Infarction (NRMI-2). J Am Coll Cardiol 1998 31 1240-1245. 

Magid DJ, Calonge BN, Rumsfeld IS, Canto JG, Frederick PD, Every NR, Barron HV National Registry of Myocardial Infarction 2 and 3 Investigators. Relation between hospital primary angioplasty volume and mortality for patients with acute MI treated with primary angioplasty vs. thrombolytic therapy. JAMA 2000 284 3131-3138. 

Angeja BG, Gibson CM, Chin R, Frederick PD, Every NR, Ross AM, Stone GW, Barron HV Participants in the National Registry of Myocardial Infarction 2-3. Predictors of door-to-balloon delay in primary angioplasty. Am J Cardiol 2002 89 1156-1161. 

Spencer FA, Goldberg RJ, Frederick PD, Malmgren J, Becker RC, Gore JM. Age and the utilization of cardiac catheterization following uncomplicated first acute myocardial infarction treated with thrombolytic therapy (The Second National Registry of Myocardial Infarction [NRMI-2]). Am J Cardiol 2001 88 107-111. 

Rogers WJ, Bowlby LJ, Chandra NC, et al. Treatment of myocardial infarction in the United States (1990 to 1993) observations from the National Registry of Myocardial Infarction. Circulation 1994 90 2103-2114. 

Canto JG, Every NR, Magid DJ, Rogers WJ, Mahngren JA, Frederick PD, French WJ, Tiefenbrunn AJ, Misra VK, Kiefe Cl, Barron HV (for the National Registry of Myocardial Infarction 2 Investigators). The volume of primary angioplasty procedures and survival after acute myocardial infarction. NEJM 2001 342(21) 1573-80. 

Figure 4.8 Temporal trends in the use of reperfusion therapy for patients with ST elevation myocardial infarction within 12 hours from symptom onset in the National Registry of Myocardial Infarction 1,2 and 3 trials. (From Ref. 86.)...

Peterson LR, Chandra NC, French WJ, et al. for the National Registry of Myocardial Infarction-2 Investigators. Reperfusion therapy in patients with acute myocardial infarction and prior coronary artery bypass graft surgery (National Registry of Myocardial Infarction-2). Am J Cardiol 1999 84 1287-1291. 

Rogers WJ, Canto JG, Barron HV, et al. for the investigators in the National Registry of Myocardial Infarction. Treatment and ontcome of myocardial infarction in hospitals with and without invasive capability. J Am CoU Cardiol 2000 35 371-379. 

Goldberg RJ, Mooradd M, Gurwitz JH, et al. Impact of time to treatment with tissue plasminogen activator on morbidity and mortality following acute myocardial infarction (The Second National Registry of Myocardial Infarction). Am J Cardiol 1998 82 259-264. 

Canto JG, Rogers WJ, Bowlby LJ, French WJ, Pearce DJ, Weaver WD. The prehospital electrocardiogram in acute myocardial infarction is its full potential being realized National Registry of Myocardial Infarction 2 Investigators. J Am CoU Cardiol 1997 29(3) 498-505. 

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