Timolol, myocardial infarction treatment

Effects of 3-blocker therapy on life-table cumulated rates of mortality from all causes over 6 years among 1884 patients surviving myocardial infarctions. Patients were randomly assigned to treatment with placebo (dashed red line) or timolol (solid blue line). 

Timolol (10 mg t.i.d.) alone or in combination with other antihypertensive agents, such as thiazide diuretics, is used in the management of hypertension. Timolol is indicated for the treatment of myocardial infarction and prophylaxis of migraine headaches. Timolol (1 drop of 0.25% solution twice daily) is effective in lowering intraocular pressure in patients with chronic open-angle glaucoma. 

Timolol is an effective antihypertensive agent. It improves exercise tolerance in patients with angina pectoris. It substantially reduces the long-term risk of sudden death and reinfarction in patients surviving acute myocardial infarction. It has been shown to reduce the size of an acute myocardial infarction when given intravenously within 4 hours after the onset of symptoms. Timolol is effective in the treatment of supraventricular arrhythmias and in certain cases of recurrent ventricular tachycardia. 

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