Prostaglandin acute myocardial infarction

Meyer WJ, Benton SL, Hoon TJ, Gauthier DW, Whiteman VE. Acute myocardial infarction associated with prostaglandin E2. Am J Obstet Gynecol 1991 165(2) 359-60. 

Figure 6.8 Urinary, 2,3-dinor-thromboxane (Tx) B2 (normal < 350 pg/mg creatinine) and 2,3-dinor-6-keto-prostaglandin (PG) (normal < 220 pg/mg creatinine) in 6h urine aliquots over 2 days in a patient admitted with unstable angina who subsequently developed an acute myocardial infarction...

In addition to their effects on coronary thrombosis, prostaglandins may play a role in modulating the degree of tissue injury in acute myocardial infarction. Infusion of prostacyclin in the isolated perfused heart limits hypoxic injury independent of its effects on tissue perfusion or platelet function, suggesting that prostacyclin exerts a direct myoprotective effect . Prostacyclin biosynthesis increases markedly following acute myocardial infarction in... 

Sharma, B., Heineman, F., Wyeth, P., Kolath, G. and Gimenez, H. (1987). Alternative intracoronary prostaglandin Ej and streptokinase infusion in acute myocardial infarction. Clin. Res., 35, 6A... 

P. is - prostaglandin that is produced by enzymatic transformation of prostaglandin endoperoxides and which dilates blood vessels. P. is chemically unstable in aqueous solutions, but the mono sodium-salt is stable as a solid and in solution. In addition, p. shows antimetastatic effects and has been used for patients with acute myocardial infarction. It has also been postulated that p. acts to stimulate platelet adenylate cyclase and to prevent the action of thrombi in phospholipid breakdown as well as platelet aggregation. In clinical practice, it is used for preventing the loss of platelets in cases wdiere the blood comes into extracorporal contact with artificial surfaces, i.e., in hemodialysis, cardiopulmonary bypass, and charcoal column perfusion for treatment of liver failure. 

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