Cytomegaloviruses

Radiation Therapeutic Radioiodine Atomic fallout infections Rubella virus Cytomegalovirus Herpes virus homlnis Toxoplasmosis... [Pg.314]

Cytomegalovirus (CMV) is a herpesvirus, which causes an inapparent infection in immunocompetent persons. Worldwide, approximately 40% of people are infected with CMV. In immunocompromised patients, transplant recipients and neonates, CMV can cause serious and potentially lethal disease manifestations like pneumonia, retinitis and blindness, hepatitis, infections of the digestive tract, deafness or mental retardation. [Pg.413]

Cytomegalovirus CMV Cytoplasmic Tyrosine Kinases Cytoskeleton Cytostatic Drugs... [Pg.1490]

Antiviral drugp interfere with viral reproduction by altering DNA synthesis. These drug are used in the treatment of herpes simplex infections of the eye, treatment in immunocompromised patients with cytomegalovirus (CMV) retinitis, and for the prevention of CMV retinitis in patients undergoing transplant. [Pg.625]

Balzarini J, Schols D, Van Laethem K, De Clercq E, Hockovd D, Masojidkova M, Holy A (2007) Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines, J Antimicrob Chemother 59 80-86 Beadle JR, Wan WB, Ciesla SL, Keith KA, Hartline C, Kern ER, Hostetler KY (2006) Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses, J Med Chem 49 2010-2015... [Pg.79]

Stuyver LJ, McBrayer TR, Thamish PM, Qark J, HoUecker L, Lostia S, Nachman T, Grier J, Bennett MA, Xie M-Y, Schinazi RE, Morrey JD, Inlander JL, Eurman PA, Otto MJ (2006) Inhibition of hepatitis C repUcon RNA synthesis by P-D-2 -deoxy-2 -fluoro-2 -C-methylcytidine a specific inhibitor of hepatitis C virus replication. Antiviral Chem Chemother 17 79-87 Sullivan V, Talarico CL, Stanat SC, Davis M, Coen DM, Biron KK (1992) A protein kinase homo-logue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells. Nature 359 85... [Pg.83]

Xiong X, Smith JL, Chen MS (1997) Effect of incorporation of cidofovir into DNA by human cytomegalovirus DNA polymerase on DNA elongation. Antimicrob Agents Chemother 41 594-599... [Pg.84]

Darke PL, Cole JL, Waxman L, Hall DL, Sardana MK, Kuo LC (1996) Active human cytomegalovirus protease is a dimer. J Biol Chem 271 7445-7449 De Francesco R, Carfi A (2007) Advances in the development of new therapeutic agents targeting the NS3 A serine protease or the NS5B RNA-dependent RNA polymerase of the hepatitis C virus. Adv Drug Deliv Rev 59 1242-1262... [Pg.104]

Margosiak SA, Vanderpool DL, Sisson W, Pinko C, Kan CC (1996) Dimerization of the human cytomegalovirus protease kinetic and biochemical characterization of the catalytic homodimer. Biochemistry 35 5300-5307... [Pg.106]

Tong L, Qian C, Massariol MJ, Bonneau PR, Cordingley MG, Lagace L (1996) A new serine-protease fold revealed by the crystal structure of human cytomegalovirus protease. Nature 383 272-275... [Pg.109]

Fig. 3 Representation of the replication cycle of cytomegalovirus showing the site of action of terminase inhibitors...

In this chapter, we have described the spectrum of antiviral activities that have been discovered beyond the world of nucleoside analogues, protease and fusion inhibitors. The compounds and mechanisms described here may one day add significantly to the armamentarium of antiviral agents, not only against Herpes Simplex, Hepatitis B and Human Immunodeficiency Virus, but also against Hepatitis C and Human Cytomegalovirus. [Pg.170]

Bogner E (2002) Human cytomegalovirus terminase as a target for antiviral chemotherapy. Rev Med Virol 12 115-127... [Pg.171]

Casado JL, Perez-Ehas MJ, Marti-Belda P, Antela A, Suarez M, Ciancas E et al. (1998) Improved outcome of cytomegalovirus retinitis in AIDS patients after introduction of protease inhibitors. J Acquir Immune Defic Syndr Hum Retrovirol 19 130-134 Catalano CE (2000) The terminase enzyme from bacteriophage lambda a DNA-packaging machine, Cell Mol Life Sci 57 128-148... [Pg.171]

Chee MS, Bankeir AT, Beck S, Bohni R, Brown CM, Cerny R, Horsnel T, Hutchinson CAI, Kouzarides T, Martignetti JA, Preddie E, Satchwell SP, Tomlinson P, Weston KM, Barrel BG (1990) Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169, Curr Top Microbiol Immunol 154 125-170 Chiu TK, Davies DR (2004) Structure and function of HIV-1 integrase. Curr Top Med Chem 4 965-977... [Pg.171]

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