Murine cytomegalovirus MCMV

Hill, A., Kleijnen, M., Schust, D., Kosinowski, U., and Ploegh, H. (1996). Murine cytomegalovirus (MCMV) encodes a 34 kDa glycoprotein, which binds to class IMHC molecules at the surface of infected cells. Abstract 410, Keystone Symposium on Cell Biology of Virus Entry, Replication and Pathogenesis. Santa Fe, NM. 

Murine cytomegalovirus (MCMV) latent viral reactivation assay ... 

The therapeutic agent should be further tested in the murine cytomegalovirus (MCMV) latent virus reactivation model if results from the influenza host resistance assay indicate a decreased functional activity for either NK, CTL, or TDAR, or a decrease in CD4+ cells as observed by immunopheno-typing. The MCMV latent virus reactivation model is discussed in detail below. The test article should be tested in the Streptococcus pneumoniae systemic model for encapsulated bacteria if immunophenotyping or histopathology, done in conjunction with the influenza host resistance model, reveals a decrease in the number of marginal zone B (MZB) cells. MZB cells are critical in host defense against bloodborne encapsulated bacteria and this host resistance assay is discussed in detail below. 

Murine Cytomegalovirus (MCMV) Latent Virus Reactivation Model... 

The critical role NK cells play in the control of infection with viruses is well-recogni2ed (French Yokoyama 2003). In the murine cytomegalovirus (MCMV) model, susceptibility to lethal infection can be overcome by a dominant allele at... 

Salazar-Mather TP, Orange JS, Biron CA. Early murine cytomegalovirus (MCMV) infection induces liver natural killer (NK) cell inflammation and protection through macrophage inflammatory protein la (MlP-la)-dependent pathways. J Exp Med 1998 187 1-14. 

If antigenic peptides do emerge in the ER, viruses can mediate retention of MHC class 1 molecules in intracellular compartments. Examples are reviewed elsewhere in this issue and include HCMV-encoded US3 and the murine cytomegalovirus (MCMV) ml52 gene product gp40. The mechanism by which US3 binds to class I molecules and retains the complex in the ER, involves a retention... 

NK natural killer CTL cytotoxicT lymphocyte TDAR T-dependent antibody response MCMV murine cytomegalovirus MZB cells marginal zone B cells TIAR T-independent antibody response. 

ORF, open-reading frame NA, not available KS, Kaposi s sarcoma KSHV, Kaposi s sarcoma-associated herpesvirus GPCR, G protein-coupled receptor CMV, cytomegalovirus MCMV, mouse cytomegalovirus MCK, murine cytomegalovirus chemokine CCL5, CC chemokine ligand 5 IFN, interferon IL, interleukin NF-kB, nuclear factor kB Tp, T helper NK, natural killer. 

Z- and ii-Phosphonates (561) and (562) derived from cyclopropavir and the corresponding cyclic phosphonates (563) and (564), have been synthesized and their antiviral activity was investigated. The Z-phosphonates (561) and (563) were effective inhibitors of replication of human and murine cytomegalovirus (HCMV and MCMV) in HFF (cell culture with two... 

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