Cytomegalovirus genomes

Chamber J et al. DNA microarrays of the complex human cytomegalovirus genome profiling kinetic class with drug sensitivity of viral gene expression. J Virol 1999 73 5757-5766... 

Huglies R, Atkinson P, Coates P, Hall S, Leibowitz S (1992) Sur al nerve biopsies in Guillain-Bane syndr ome Axonal degeneration and macrophage-associated demyelination and absence of cytomegalovirus genome. Muscle Nerve 15 568—575. 

Vink C> Beuken E, Bruggeman CA. Complete DNA sequence of the rat cytomegalovirus genome. 

Vieira J. Genes in the Hindlll J fragment of the murine cytomegalovirus genome are dispensable for growth in cultured cells insertion mutagenesis with a lacZ/gpt cassette. J Virol 1994 68(8) 4837-46. 

Bold S, Ohlin M, Garten W, Radsak K (1996) Structural domains involved in human cytomegalovirus glycoprotein B-mcdiated cell-cell fusion. J Gen Virol 77 2297 2302 Boriskin YS, Moore P, Murday AJ, Booth JC, Butcher PD (1999) Human cytomegalovirus genome sequences in lymph nodes. Microbes Infection 1 279 283 Broxmeyer HE, Kim CH (1999) Regulation of hematopoiesis in a sea of chemokine family members with a plethora of redundant activities. Exp Hematol 27 1113 1123... 

Figure 3.9 Mode of action for antisense drags. An example is Fomivirsen (Vitravene, Isis Pharmaceuticals), which is a 21-nucleotide phosphorothioate that binds to the complementary mRNA of cytomegalovirus and blocks the translation process. Cytomegalovirus is a virus that belongs to the herpes group. (Source Chang YT. Keyword of the Post Genomic Era—Library, New York University, New York, 2002. http //www. nyu.edu/classes/ytchang/book/e003.html [accessed September 10, 2002].)...

Herpesviruses range in size from 120 to 300 nm and have DNA genomes and outer lipid membranes (envelopes). As enveloped viruses, herpesviruses are sensitive to drying and adverse conditions. Herpesviruses are spread by inoculation of susceptible mucous membranes or direct cell-to-cell contact. Over 100 herpesviruses have been identified, but only 5 cause human eye infections with any frequency herpes simplex virus-1 (HSV-1), herpes simplex virus-2 (HSV-2), varicella zoster virus (VZV), cytomegalovirus (CMV), and Epstein-Barr virus. Herpesviruses can cause blepharitis, conjunctivitis, epithelial and stromal keratitis, uveitis, retinitis, and ARN. HSV-1 is the most frequent cause of primary and recurrent eye disease. The host immime system influences the rates of reactivation. Immimocompromised patients tend to have more frequent reactivations and more severe disease manifestations. The strain of virus also affects the... 

Bender B, Georgel P, Rutschmann S et al 2005 Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV). Brief Funct Genomic Proteomic 4 203—213 Carninci P, Kasukawa T, Katayama S et al 2005 The transcriptional landscape of the mammalian genome. Science 309 1559—1563... 

Borst EM, Hahn G, Koszinowski IJH, Mes.serle M (1999) C loning of the human cytomegalovirus (HCMV) genome as an infectious bacterial artificial chromosome in Escherichia coli a new approach for construction of HCMV mutants. J Virol 73 8320 8329... 

Pandey A, Mann M (2000) Proteomics to study genes and genomes. Nature 405 837 -846 Penfold ME, Dairaghi DJ, Duke GM, Saederup N, Mocarski ES, Kemble GW, Schall TJ (1999) Cytomegalovirus encodes a potent alpha chemokine. Proc Natl Acad Sci USA 96 9839 -9844 Rawlinson WD, Farrell HE, Barrell BG (1996) Analysis of the complete DNA sequence of murine cytomegalovirus. J Virol 70 8833 8849... 

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