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Cytomegalovirus-induced retinitis

V itravene, a phosphorothioate oligonucleotide designed to inhibit cytomegalovirus-induced retinitis, has been shown to be safe and effective in the treatment of this disease after in-travitreal injection and has been approved for sale by regulatory agencies in the United States, Europe, and South America (for review, see Ref 240). [Pg.138]

Currently, there is only one antisense drug on the market— Vitravene (active ingredient fomivirsen) for the treatment of cytomegalovirus (CMV)-induced retinitis (inflammation of the retina) in AIDS patients. Fomivirsen has 21 nucleotides complementary to a CMV mRNA sequence, which is necessary for the production of infectious virus. Two examples of experimental antisense drugs are provided in Exhibit 3.15, while Table 3.1 lists other antisense drugs in clinical phase. [Pg.81]

Cidofovir inhibition of viral DNA polymerase Cytomegalovirus indicated only for virus-induced retinitis 2-3 ... [Pg.469]

See other pages where Cytomegalovirus-induced retinitis is mentioned: [Pg.187]    [Pg.573]    [Pg.32]    [Pg.468]    [Pg.187]    [Pg.68]    [Pg.86]    [Pg.187]    [Pg.573]    [Pg.32]    [Pg.468]    [Pg.187]    [Pg.68]    [Pg.86]    [Pg.246]    [Pg.132]    [Pg.1224]    [Pg.229]    [Pg.1145]    [Pg.246]    [Pg.599]    [Pg.180]   
See also in sourсe #XX -- [ Pg.86 ]



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Cytomegalovirus

Cytomegalovirus retinitis

Retin

Retinal

Retinitis

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