Congenital cytomegalovirus

Boparrrra SB, Pass RF, Britt WJ (1992) Symptomadc congenital cytomegalovirus irrfecdon Neonatal morbidity and mortality. Pediatr Irrfect Dis J 11 93—99. 

Non-cirrhotic portal hypertension in congenital cytomegalovirus infection. Hepatology 1984 4 684- 686... 

Bopaima SB, Fowler KB, Vaid Y (1997) Neuroradiographic findings in the newborn period and long-term outcome in children with symptomatic congenital cytomegalovirus infection. Pediatrics 99 409-f 14. 

Suzuki, Y., Toribe, Y., Mogami, Y., Yanagihara, K., Nishikawa, M. (2008). Epilepsy in patients with congenital cytomegalovirus infection. Brain Dev. 30 420—424... 

C.S. Peckham, 0. Stark, J.A. Dudgeon, J.A. Martin and G. Hawkins, Congenital cytomegalovirus infection a cause of sensorineural hearing loss. Arch. Pis. Child. 62 1233-1237 (1987). 

In a retrospective case-series of 23 infants with culture-proven congenital cytomegalovirus infection who had been treated with ganciclovir for 6 weeks, followed by oral valganciclovir to the age of 12 months, the most common adverse reaction was neutropenia ( =12) it was severe in two infants, with absolute neutrophil counts below 500 X 10 /1 [12 ]. Treatment was withheld imtil the neutrophil count returned to normal no further intervention was required. Neutropenia occurred only within the first 3 months of treatment and mainly during the first 6 weeks of intravenous ganciclovir administration. 

Amir J, Wolf DG, Levy L Treatment of symptomatic congenital cytomegalovirus infection with intravenous ganddovir followed by long-term oral valgandclovir. Eur J Pediatr 2010 169(9) 1061-7. 

Cytomegalovirus (CMV) Enveloped, icosahedral particles 150nm in diameter CMV is generally acquired in childhood as a subclinical infection. About 50% of adults carry the virus in a dormant state in white blood cells. The virus can cause severe disease (pneumonia, hepatitis, encephalitis) in immunocompromised patients. Primary infections during pregnancy can induce serious congenital abnormalities in the fetus... 

Cytomegalovirus (CMV) Causes cold-like symptoms in healthy individuals, but more severe effects in immunocompromised persons. Causes congenital handicap in infants whose mothers contracted CMV during pregnancy... 

The causes of peliosis hepatis are varied and include anabolic or androgenic steroids, oestrogens (52), azathio-prine, arsenic, vinyl chloride, tamoxifen and danazol as well as tuberculosis, histiocytosis, leishmaniasis, leprosy, carcinoma, sprue, liver abscess, cytomegalovirus infection, glycogenosis (type I) (14) and marasmus. (46) Congenital (angiomatous) abnormality of the vessels may also be a contributory factor. (5) The respective development of peliosis hepatis is still unclear. 

Both 2-amino-4-mercaptopurine (XLVII) and its 9- -D-ribofuranOside have high activity in vitro against cytomegalovirus. This virus is repeatedly found in patients on immunosuppressive treatment, is highly infective and can produce severe congenital disease in newborn infants. 

Kovacs AA, Churchill M A, Wood D, Mascola L, Zaia JA (1993) Molecular and epidemiologic evaluations of a cluster of cases of Menetrier s disease associated with cytomegalovirus. Pediatr Infect Dis J 12 1011-1014 Kroes EJ, Festen C (1998) Congenital microgastria a case report and review of the literature. Pediatr Surg Int 13 416-418... 

For example, in non endemic areas, as much as 12 % of congenital sensorineural hearing loss is due to congenital infection caused by cytomegalovirus (27-29). 

Cytomegalovirus One of a widespread and diverse group of herpsviruses that often produces no symptoms in normal adults but can severely affect AIDS patients and congenitally infected children. 

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