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Cytomegalovirus cidofovir

Xiong X, Smith JL, Chen MS (1997) Effect of incorporation of cidofovir into DNA by human cytomegalovirus DNA polymerase on DNA elongation. Antimicrob Agents Chemother 41 594-599... [Pg.84]

Harada K, Eizuru Y, Isashiki Y, Ihara S, Minamishima Y (1997) Genetic analysis of a clinical isolate of human cytomegalovirus exhibiting resistance against both ganciclovir and cidofovir. Arch Virol 142 215-225... [Pg.172]

Vistide Cidofovir injection Gilead Sciences Cytomegalovirus retinitis in AIDS patients... [Pg.695]

In 1996 cidofovir was approved for the treatment of AIDS-related cytomegalovirus retinitis. It is already a monophosphate and does not need activation by viral enzymes. [Pg.420]

Cidofovir Vistide Treatment of cytomegalovirus (CMV) retinitis in immunocompromised patients... [Pg.526]

Wolf DL, Rodriguez CA, Mucci M, et al. Pharmacokinetics and renal effects of cidofovir with a reduced dose of probenecid in HIV-infected patients with cytomegalovirus retinitis. J Clin Pharmacol. 2003 43 43-51. [Pg.544]

Azetidine 25 has shown promising anti-human cytomegalovirus (HCMV) activity. Human cytomegalovirus is a ubiquitous member of the herpes virus family. The EGso value obtained for this compound has been found to be similar to that of the standard reference compound ganciclovir and slightly better than that of cidofovir... [Pg.35]

Cidofovir inhibition of viral DNA polymerase Cytomegalovirus indicated only for virus-induced retinitis 2-3 ... [Pg.469]

The treatment for smallpox is primarily supportive. Research is ongoing into antiviral therapies for smallpox but currently therapy for patients infected with smallpox remains supportive, with intravenous fluids, pain medications, and antibiotics as needed for secondary bacterial infections (Henderson, 1999). Cidofovir, an antiviral agent used primarily against cytomegalovirus infection, has shown some promise against orthopox viruses such as vaccinia and cowpox in animal studies (De Clercq, 2002). Currently it is approved in its IV form for use in the treatment of adverse effects of smallpox vaccination (CDC, 2003). [Pg.415]

Ongoing treatment of healed cytomegalovirus retinitis after immime recovery does not appear to protect against the development of immune recovery uveitis.The risk is so significant that some recommend that other antiviral treatments for cytomegalovirus retinitis be substituted for cidofovir. [Pg.718]

Keep vigilant in any patient on cidofovir, especially if it has previously been used to treat cytomegalovirus. [Pg.797]

Keywords Encephalitis Heipes simplex virus type 1 Varicella zoster virus Cytomegalovirus West Nile virus Acyclovir Valacyclovir Ganciclovir Cidofovir Famciclovir Foscamet Latencyneurological disorders Lifecycle... [Pg.327]

Plosker GL, Noble S (1999) Cidofovir A review of its use in cytomegalovirus rediiids in padeiits widi AIDS. Drugs 58 325—345. [Pg.340]

Cidofovir (iS -l-3-hydroxy-2-phosphonylmethoxypropyl-cjrtosine), also known as HPMPC, is a nncleotide analogue with potent activity against cytomegalovirus (CMV) in vitro and in vivo. [Pg.771]

Cidofovir has been used to treat 14 patients with cytomegalovirus infection after stem-cell transplantation no adverse effects were reported in this small study (1). [Pg.771]

Uveitis (8) and cystoid macular edema (9) are recognized risks associated with cidofovir treatment for cytomegalovirus retinitis. The latter is almost certainly an... [Pg.771]

In a rare cytomegalovirus comparison trial, a ganciclovir insert (an intraocular implant) plus oral ganciclovir was compared with intravenous cidofovir (18). Based on data from 61 patients (the trial was stopped early owing to low recruitment), cidofovir was associated with a raised serum creatinine concentration of 142 pmol/l (1.6 mg/dl) or greater (0.48 per person-year), 3+ or greater proteinuria (0.29 per person-year), uveitis (0.35 per person-year), and neutropenia (0.11 per person-year). [Pg.772]

Kirsch LS, Arevalo JF, Chavez de la Paz E, Munguia D, de Clercq E, Freeman WR. Intravitreal cidofovir (HPMPC) treatment of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome. Ophthalmology 1995 102(4) 533-42. Erratum in Ophthalmology 1995 102(5) 702. [Pg.772]

Berenguer J, Mallolas J, Padilla B, Colmenero M, Santos I. Intravenous cidofovir for compassionate use in AIDS patients with cytomegalovirus retinitis. Spanish Cidofovir Study Group. Clin Infect Dis 2000 30(l) 182-4. [Pg.772]

Ambati J, Wynne KB, Angerame MC, Robinson MR. Anterior uveitis associated with intravenous cidofovir use in patients with cytomegalovirus retinitis. Br J Ophthalmol 1999 83(10) 1153-8. [Pg.772]

Kersten AJ, Althaus C, Best J, Sundmacher R. Cystoid macular edema following immune recovery and treatment with cidofovir for cytomegalovirus retinitis. Graefes Arch Chn Exp Ophthalmol 1999 237(ll) 893-6. [Pg.772]

Akler ME, Johnson DW, Burman WJ, Johnson SC. Anterior uveitis and hypotony after intravenous cidofovir for the treatment of cytomegalovirus retinitis. Ophthalmology 1998 105(4) 651-7. [Pg.772]

Jabs DA, Freeman WR, Jacobson M, Murphy R, Van Natta ML, Meinert CL. Long-term follow-up of patients with AIDS treated with parenteral cidofovir for cytomegalovirus retinitis the HPMPC Peripheral Cytomegalovirus Retinitis Trial. The Studies of Ocular Complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group. AIDS 2000 14(11) 1571-81. [Pg.772]

Lalezari JP, Stagg RJ, Kuppermann BD, Holland GN, Kramer F, Ives DV, Youle M, Robinson MR, Drew WL, Jaffe HS. Intravenous cidofovir for peripheral cytomegalovirus retinitis in patients with AIDS. A randomized, controlled trial. Ann Intern Med 1997 126 257-263. [Pg.393]

Polls MA, Spooner KM, Baird BF, Manischewitz JF, Jaffe HS, Fisher PF, Falloon J, Davey RT Jr, Kovacs JA, Walker RE, Whitcup SM, Nussenblatt RB, Lane HC, Masur H. Anticytomegaloviral activity and safety of cidofovir in patients with human immunodeficiency virus infection and cytomegalovirus viremia. Antimicrob Agents Chemother 1996 39 882-886. [Pg.393]

See other pages where Cytomegalovirus cidofovir is mentioned: [Pg.188]    [Pg.198]    [Pg.55]    [Pg.81]    [Pg.165]    [Pg.174]    [Pg.132]    [Pg.468]    [Pg.188]    [Pg.198]    [Pg.717]    [Pg.756]    [Pg.334]    [Pg.337]    [Pg.334]    [Pg.337]    [Pg.771]    [Pg.772]    [Pg.773]    [Pg.773]    [Pg.1480]    [Pg.393]   
See also in sourсe #XX -- [ Pg.385 ]

See also in sourсe #XX -- [ Pg.401 , Pg.402 ]



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Cytomegalovirus

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