Cytomegalovirus retinitis treatment

Vitravene Study Group (2002) A randomized controlled chnical trial of intravitreous fomivirsen for treatment of newly diagnosed peripheral cytomegalovirus retinitis in patients with AIDS, Am J Ophthalmol 133 467 74... [Pg.262]

Cytomegalovirus (CMV) retinitis Treatment of CMV retinitis in patients with AIDS. Combination Combination therapy with ganciclovir for patients who have relapsed after monotherapy with either drug. [Pg.1736]

In 1996 cidofovir was approved for the treatment of AIDS-related cytomegalovirus retinitis. It is already a monophosphate and does not need activation by viral enzymes. [Pg.420]

A small number of biopharmaceuticals are delivered by nonparenteral means. Recombinant DNase is given by inhalation aerosol to reduce the viscosity of mucus in the lungs of patients with cystic hbrosis. A platelet-derived growth factor in the form of a gel is administered topically for wound healing. Several hormones and peptides are administered in solution by the intranasal route. A solution of an antisense drug used for the treatment of cytomegalovirus retinitis is injected directly into the eye. [Pg.119]

Indications Treatment of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome... [Pg.36]

Chang M, Dunn JP Ganciclovir implant in the treatment of cytomegalovirus retinitis. Expert Rev Med Devices 2005 2 421-427. [Pg.52]

Martin DF, Dunn JP Davis JL, et al. Use of the ganciclovir implant for the treatment of cytomegalovirus retinitis in the era of potent antiretroviral therapy recommendations of the international AIDS society—USA panel. Am J Ophthalmol 1999 127 329-339. [Pg.52]

Ongoing treatment of healed cytomegalovirus retinitis after immime recovery does not appear to protect against the development of immune recovery uveitis.The risk is so significant that some recommend that other antiviral treatments for cytomegalovirus retinitis be substituted for cidofovir. [Pg.718]

Uveitis (8) and cystoid macular edema (9) are recognized risks associated with cidofovir treatment for cytomegalovirus retinitis. The latter is almost certainly an... [Pg.771]

Kirsch LS, Arevalo JF, Chavez de la Paz E, Munguia D, de Clercq E, Freeman WR. Intravitreal cidofovir (HPMPC) treatment of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome. Ophthalmology 1995 102(4) 533-42. Erratum in Ophthalmology 1995 102(5) 702. [Pg.772]

Kersten AJ, Althaus C, Best J, Sundmacher R. Cystoid macular edema following immune recovery and treatment with cidofovir for cytomegalovirus retinitis. Graefes Arch Chn Exp Ophthalmol 1999 237(ll) 893-6. [Pg.772]

Akler ME, Johnson DW, Burman WJ, Johnson SC. Anterior uveitis and hypotony after intravenous cidofovir for the treatment of cytomegalovirus retinitis. Ophthalmology 1998 105(4) 651-7. [Pg.772]

Lalezari JP, Holland GN, Kramer F, McKinley GF, KemperCA, Ives DV, Nelson R, Hardy WD, Kupperman BD, Northfelt DW, Youle M, Johnson M, Lewis RA, Weinberg DV, Simon GL, Wolitz RA, Ruby AE, Stagg RJ, Jaffe HS. Randomized, controlled trial of the safety and efficacy of intravenous cidofovir for the treatment of relapsing cytomegalovirus retinitis in patients with AIDS. J AIDS Hum Retrovirol 1998 17 339-344. [Pg.393]

Jacobson MA, O Donnell JJ, Mills J. Foscarnet treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome. Antimicrob Agents Chemother 1989 33 736-741. [Pg.394]

Farese RV Jr, Schambelan M, Flollander FI, Stringari S, Jacobson MA. Nephrogenic diabetes insipidus associated with foscarnet treatment of cytomegalovirus retinitis. Ann Intern Med 1990 112 955-956. [Pg.394]

Musch D, Martin D, Gordon J, et al. Treatment of cytomegalovirus retinitis with a sustained-release ganciclovir implant. N Engl J Med 1997 337 83-90. [Pg.2277]

Palestine A, Polis M, de Smet M, et al. A randomized, controlled trial of foscarnet in the treatment of cytomegalovirus retinitis in patients with AIDS. Ann Intern Med 1991 115 665-673. [Pg.2277]

Studies of Ocular Complications of AIDS Research Group in Collaboration with the AIDS Clinical Trial Group. Combination foscarnet and ganciclovir therapy vs monotherapy for the treatment of relapsed cytomegalovirus retinitis in patients with AIDS. Arch Ophthamol 1996 114 23-33. [Pg.2277]

Ussery FM, Gibson SR, Conklin RH, et al. Intravitreal ganciclovir in the treatment of AIDS-associated cytomegalovirus retinitis. Ophthalmology 1988 95 640-648. [Pg.24]

Sanborn GE, Anand R, Torti RE, et al. Sustained-release ganciclovir therapy for treatment of cytomegalovirus retinitis. Arch Ophthalmol 1992 110 188-195. [Pg.24]

Kunou N, Ogura Y, Yasukawa T, et al. Long-term sustained release of ganciclovir from biodegradable scleral implant for the treatment of cytomegalovirus retinitis. J Control Release 2000 68 263-271. [Pg.190]

Hatton MP, Duker JS, Reichel E, Morley MG, Puliafito CA. Treatment of relapsed cytomegalovirus retinitis with the sustained-release ganciclovir implant. Retina 1998 18 50-55. [Pg.224]

Roth DB, Feuer WJ, Blenke AJ, Davis JL. Treatment of recurrent cytomegalovirus retinitis with the ganciclovir implant. Am J Ophthalmol 1999 127 276-282. [Pg.224]

Freeman WR, Henderly DE, Wan WL, et al. Prevalence, pathophysiology, and treatment of rhegmatogenous retinal detachment in treated cytomegalovirus retinitis. Am J Ophthalmol 1987 103 527. [Pg.345]

Jabs DA, Newman C, De Bustros S, Polk BF. Treatment of cytomegalovirus retinitis with ganciclovir. Ophthalmology 1987 94 824. [Pg.346]

Davis JL, Taskintuna I, Freeman WR, et al. Iritis and hypotony after treatment with intravenous cidofovir for cytomegalovirus retinitis. Arch Ophthalmol 1997 115 733-740. [Pg.346]

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