Human cytomegalovirus HCMV

In order to identify novel lead compounds with antiviral effects, methanol and aqueous extracts of some medicinal plants in the Zingiberaceae family were screened for inhibition of proteases from human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and human cytomegalovirus (HCMV). By bioassay-guided fractionation, eight fiavones were isolated from the black rhizomes of Kaempferia parviflora Wall, ex Baker. The most effective inhibitors, 5-hydroxy-7-methoxyfiavone and 5,7-dimethoxyflavone, inhibited HIV-1 protease, with an inhibitory concentration 50 (IC50) values of 19 0,M. Moreover, 5-hydroxy-3,7-dimethoxyflavone inhibited HCV protease and HCMV protease, with IC50 values of 190 and 250 pM, respectively. 

The product inhibits replication of human cytomegalovirus (HCMV) via an antisense mechanism. Its nucleotide sequence is complementary to a sequence in mRNA transcripts of the major immediate early region (IE2 region) of HCMV. These mRNAs code for several essential viral proteins and blocking their synthesis effectively inhibits viral replication. 

A range of chiral (ly)-proline derivatives, for example 211, have been shown to be active serine protease inhibitors and are active antivirals of human cytomegalovirus (HCMV) <2003JME4428>. 

HORMONES - ANTERIORPITUITARY-LIKE HOMONES] (Vol 13) Human cytomegalovirus (HCMV)... 

Human cytomegalovirus (HCMV) is a ubiquitous member of the herpes virus family. Although most infections are asymptomatic, severe manifestations of HCMV can be seen in individuals whose immune system has been weakened by... 

Abstract The inhibitory action of polyanionic substances on virus replication was reported more than 50 years ago. Seaweeds, marine invertebrates, and higher plants represent abundant sources of novel compounds of proved antiviral activity. Natural sulfated polysaccharides (SPs) are potent in vitro inhibitors of a wide variety of enveloped viruses, such as herpes simplex virus (HSV) types 1 and 2, human immunodeficiency virus (HIV), human cytomegalovirus (HCMV), dengue virus (DENV), respiratory syncytial virus (RSV), and influenza A virus. Several polysulfate compounds have the potential to inhibit virus replication by blocking the virion binding to the host cell. In contrast, their in vivo efficacy in animal and human systemic infections has undesirable draw-... 

Pujol et al. in chapter eight, reviews the chemistry, origin and antiviral activities of naturally occurring sulfated polysaccharides for the prevention and control of viral infections such as HIV-1 and -2, human cytomegalovirus (HCMV), dengue virus (DENV), respiratory syncytial virus (RSV), and influenza A virus. 

Human cytomegalovirus (HCMV) disease is the most common life-threatening opportunistic viral infection in the inmunocompromised. HCMV protease, a serine protease, plays a critical role in capsid assembly and viral maturation and is an attractive target for antiviral chemotherapy. Slater et al investigated the interaction of various 1,4-naphthoquinones derivatives with HCMV protease. They identified potent irreversible naphthoquinones inhibitors of HCMV protease which covalently modify... 

Activity against human cytomegalovirus (HCMV) and herpes simplex [342]... 

HSV-1. See Herpes simplex virus 1 (HSV-1) Human cytomegalovirus (HCMV), 384 Human immunodeficiency virus (HIV), 3,388 E. coli and, 3... 

Phosphonoformate (22) (Fig. 17.17) is an antiviral agent that is used clinically in the treatment of herpes simplex virus (HSV) and human cytomegalovirus (HCMV) (91). It acts as a product analog, blocking the pyrophosphate-binding site, in the reaction catalyzed by DNA polymerase (Equation 17.35). It is also effective, using the same mechanism, against HIV reverse transcriptase (91). 

Cope AV, Sabin C, Burroughs A, RoUes K, Griffiths PD, Emery VC. Interrelationships among quantity of human cytomegalovirus (HCMV) DNA in blood, donor-recipient serostatus, and administration of methylprednisolone as risk factors for HCMV disease following liver transplantation. J Infect Dis 1997 176 1484-90. 

Trifluridine, C10H11F3N2O5, (5-trifluoromethyl-2,-deoxyuridine [70-00-8], F3TdU, 14) was first prepared (30) in 1962. It is used for topical therapy of herpes virus-infected eyes. It is especially useful for treating infections that are resistant to IdU therapy. Like IdU, trifluridine is incorporated into DNA in place of thymidine in both infected and uninfected cells. But it is 10 times more potent than IdU against herpes keratitis in rabbits and 10 times more soluble in water. Trifluridine is also useful in treating human cytomegalovirus (HCMV), but its toxicity to bone marrow may limit its clinical use. 

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