Cytomegalovirus pathogenesis

Hill, A., Kleijnen, M., Schust, D., Kosinowski, U., and Ploegh, H. (1996). Murine cytomegalovirus (MCMV) encodes a 34 kDa glycoprotein, which binds to class IMHC molecules at the surface of infected cells. Abstract 410, Keystone Symposium on Cell Biology of Virus Entry, Replication and Pathogenesis. Santa Fe, NM. 

Shanley JD, Jorday MC, Cook ML, Stevens JG. Pathogenesis of reactivated latent murine cytomegalovirus infection. Am J Pathol 1979 95(l) 67-80. 

Beisser PS. The R33 G protein-coupled receptor gene of rat cytomegalovirus plays an essential role in the pathogenesis of viral infection. J Virol 1998 72(3) 2352-63. 

Albrecht T. Cell activation signals and the pathogenesis of human cytomegalovirus. Intervirology 1990 31(2-4) 68-75. 

Messerle M, Hahn G, Brune W, Koszinowski UH (2000) Cytomegalovirus bacterial artificial chromosomes a new herpesvirus vector approach. Adv Virus Res 55 463 -478 Mocarski-ES J, Kemble GW (1996) Recombinant cytomegaloviruses for study of replication and pathogenesis. Intervirology 39 320 330... 

Cytomegalovirus (CMV) is a ubiquitous beta-herpesvirus that has the distinguishing characteristic of all herpesviruses, the ability to persist in the host. Persistent CMV causes serious infections such as interstitial pneumonia, gastrointestinal mucosal ulceration, retinitis, and hepatitis in immunosuppressed patients. Elucidating mechanisms of CMV persistence is critical to a complete model of pathogenesis as CMV infection, morbidity, and mortality often are the result of dissemination of virus acquired before the onset of immunosuppression. 

Sinzger C, Jahn G (1996) Human cytomegalovirus cell tropism and pathogenesis. Intervirology 39 302 319 Sinzger C. Knapp J, Plachter B, Schmidt K. Jahn G (1997) Quantification of replication of clinical cytomegalovirus isolates in cultured endothelial cells and fibroblasts by a focus expansion assay. J Virol Methods 63 103 112... 

Bason, C., Corrocher, R., Lunardi, C., Puccetti, P., Olivieri, O., Girelli, D., Navone, R., Beri, R. et al. (2003) Interaction of antibodies against cytomegalovirus with heat-shock protein 60 in pathogenesis of atherosclerosis. Lancet, 362, 1971-1977. 

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