Cytomegalovirus , Vitravene

Vitravene Study Group (2002) A randomized controlled chnical trial of intravitreous fomivirsen for treatment of newly diagnosed peripheral cytomegalovirus retinitis in patients with AIDS, Am J Ophthalmol 133 467 74... [Pg.262]

Developed by the US company, Isis, Vitravene is used to treat cytomegalovirus (CMV) retinitis in AIDS patients. It is synthesized chemically and formulated as a sterile solution (6.6 mg active drug/ml) in WFI using a bicarbonate buffer to maintain a final product pH of 8.7. [Pg.450]

Figure 3.9 Mode of action for antisense drags. An example is Fomivirsen (Vitravene, Isis Pharmaceuticals), which is a 21-nucleotide phosphorothioate that binds to the complementary mRNA of cytomegalovirus and blocks the translation process. Cytomegalovirus is a virus that belongs to the herpes group. (Source Chang YT. Keyword of the Post Genomic Era—Library, New York University, New York, 2002. http //www. nyu.edu/classes/ytchang/book/e003.html [accessed September 10, 2002].)...

Currently, there is only one antisense drug on the market— Vitravene (active ingredient fomivirsen) for the treatment of cytomegalovirus (CMV)-induced retinitis (inflammation of the retina) in AIDS patients. Fomivirsen has 21 nucleotides complementary to a CMV mRNA sequence, which is necessary for the production of infectious virus. Two examples of experimental antisense drugs are provided in Exhibit 3.15, while Table 3.1 lists other antisense drugs in clinical phase. [Pg.81]

G. Other applications The combination of Vitravene and ganciclovir is under investigation for AIDS-related cytomegalovirus... [Pg.333]

The first antisense drug Vitravene has now been approved for the treatment of patients with cytomegalovirus-induced... [Pg.31]

Vitravene (fomivirsen, ISIS 2922) Human cytomegalovirus IE-2 gene CMV retinitis Intravitreal Isis/Ciba Vision... [Pg.94]

Vitravene (fomivirsen Antisense FDA approved Inhibitor of immediate early region 2 Cytomegalovirus retinitis... [Pg.227]

Vitravene, a phosphorothiolate oligonucleotide, receives FDA approval for treatment of cytomegalovirus (CMV) retinitis in HIV-1-in-fected individuals. [Pg.692]

Vitravene Fomiviren sodium Ciba Vision 8/1998 Cytomegalovirus retinitis NA... [Pg.1426]

Vitravene Fomivirsen Isis Past marketed product withdrawn Cytomegalovirus Intravitreal injection... [Pg.35]

Vitravene (Fomivirsen an antisense oligonucleotide) ISIS Pharmaceuticals treatment of cytomegalovirus retinitis in AIDS patients 1998 (US)... [Pg.40]

Vitravene (fomivirsen sodium, ISIS Pharmaceuticals see Table 9) remains the only antisense-based biopharmaceutical approved for general medical use (see also Part III, Chapter 3). The product is a 21-base phosphorothioate nucleotide that displays a base sequence complementary to certain human cytomegaloviral mRNA transcripts. Its administration inhibits viral replication through an antisense mechanism. Approved in the US in 1998 and in the EU in 1999, the product is indicated for the treatment of cytomegalovirus retinitis by intraocular injection in AIDS patients. It was withdrawn from the EU market in May 2002 for commercial reasons. [Pg.48]

The first of only two therapeutic oligonucleotides that have been approved for human use as of writing is fomvirsen (Vitravene). It was approved by the FDA in 1998 for the local treatment of cytomegalovirus retinitis. This compound represents the original type of therapeutic... [Pg.355]

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