Colorectal cancers Lynch syndrome risks

The proposed model of RER+ colorectal cancers suggests that the Lynch syndrome represents a new variation on the central theme of autosomal dominant cancer predisposition. Knudson s prediction of a shortened carcinogenesis among at-risk people applies to Lynch syndrome Sporadic RER+ CRCs exist and a subset of them have acquired mutations inactivating both alleles of a known MMR gene (B. Liu et al., 1995). On the other... 

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