Carcinomas squamous cell

LRP1B Loss-of-function (sporadic) Esophageal squamous cell carcinoma, nonsmall-cell lung cancer... 

Vitamin D3 (VD3) and retinoids synergistically inhibit the growth and progression of squamous cell carcinomas and actinic keratoses in chronically sun exposed skin. One reason for this synergism may be the direct influence of VD3 on the isomerization and the metabolism of RA. Here, VD3 inhibits the isomerization of 13-cis-RA to the more receptor active all-trans and 9-cis-isomers. Moreover, the VD3 derivative secocholestra-trien-l,3,24-triol (tacalcitol), used for the treatment of severe keratinizing disorders inhibits 4-hydroxylation of all-ri ans-RA. 

ADCC. Cetuximab is approved for treatment of metastatic colorectal cancer (CRC) and squamous cell carcinoma of the head and neck (SCCHN). Interestingly, an adverse event, acneiform rash seems to correlate with a better response to cetuximab, while there is no such correlation with expression levels of EGFR assessed by immunohistochemistry. Further side effects are rare infusion reactions and hypomagnesia. Two other anti-EGFR antibodies approved for clinical use are the fully human antibody panitumumab (Vectibix)... 

Developments such as tenderness, induration, erosions, and enlarging diameter may herald evolution into squamous cell carcinoma. 

Typical of the vermilion of the lower lip. Diffuse scaling, with a blotchy and atrophic appearance. When erosions appear, the occurrence of a squamous cell carcinoma must be considered. 

Treatment of AK is motivated by its potential for progression to invasive squamous cell carcinoma and its cosmetic liability and/or discomfort. 

Studies on the mechanism of antitumor elfect of bleomycin on squamous cell carcinoma, H. Umezawa, T. Takeuchi, S. Hori, T. Sawa, M. Ishizuka, T. Ichikawa, and T. Komai, J. Antibiot., 25 (1972) 409-420. 

There is a bath PUVA and an oral PUVA. Bath PUVA therapies involve soaking in a bath of psoralens liquid for 15 minutes prior to UVA treatment. Oral PUVA involves taking an oral psoralens capsule the day prior to a UVA treatment. Oral psoralens such as methoxsalen cause nausea in many patients. Other adverse effects of PUVA include photosensitivity, which necessitates the use of eye protection and UVA-blocking sunscreen for 24 hours after a PUVA treatment macular melanosis at exposed sites (PUVA lentigines) and increased risk of skin cancers, especially squamous cell carcinoma.21... 

Genital warts, caused by the human papillomavirus (HPV), are regularly encountered in primary care. Responsible for various visible, keratotic, and non-keratotic manifestations, HPV has nearly 120 noted strains, some of which have been linked to squamous cell carcinoma.20... 

Superficial Spreading Nodular Lentigo Maligna Melanoma Acral Lentiginous Basal Cell Carcinoma Squamous Cell Carcinoma... 

Hypercalcemia occurs in 10% to 30% of patients with cancer during the course of their disease. The most common tumor types associated with hypercalcemia are breast cancer squamous cell carcinomas of the head, neck, and lung and renal cancer. 

Ding Y, Shimada Y, Maeda M, et al. Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma. Clin Cancer Res 2003 9 3406-3412. 

Wang J, Hunt JL, Gooding W, et al. Expression pattern of chemokine receptor 6 (CCR6) and CCR7 in squamous cell carcinoma of the head and neck identifies a novel metastatic phenotype. Cancer Res 2004 64 1861-1866. 

A 2-year carcinogenicity bioassay of tricresyl phosphate in mice and rats showed no evidence of carcinogenicity in these species (NTP 1994). Doses (consumed in feed) were <37 mg/kg/day in mice and < 15 mg/kg/day in rats. Dietary administration of tributyl phosphate was associated with transitional and squamous cell carcinomas of the bladder in rats after 2 years of exposure at 143.3 mg/kg/day (FMC 1994a). An increased incidence of hepatocellular adenomas in the liver was observed in mice after dietary administration of 455 mg/kg/day tributyl phosphate for 18 months (FMC 1994b). 

Ostergaard, M., Wolf, H., Omtoft, T. F., and Celis, J. E. (1999). Psoriasin (S100A7) A putative urinary marker for the follow-up of patients with bladder squamous cell carcinomas. Electrophoresis 20, 349-354. 

He, Q.Y., Chen, J., Kung, H.F., Yuen, A.P., Chiu, J.F. (2004). Identification of tumor-associated proteins in oral tongue squamous cell carcinoma by, proteomics. Proteomics 4,... 

Villaret DB et al. Identification of genes overexpressed in head and neck squamous cell carcinoma using a combination of complementary DNA subtraction and microarray analysis. Laryngoscope 2000 11 374-381. 

Ostergaard M et al. Proteome profiling of bladder squamous cell carcinomas identification of markers that define their degree of differentiation. Cancer Res 1997 57 4111 117. 

Oseroff, A. R., Ohuoha, D., Ara, G., Whittaker, D., Murphy, G., Foley, J. and Cincotta, L. (1986). Intramitochondrial photosensitizers allow selective photochemotherapy of human squamous-cell carcinoma (See). J. Invest. Dermatol. 86, 498. 

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