Colorectal cancer surgical

Surgical intervention is a potential treatment option in patients with complications such as fistulae or abscesses, or in patients with medically refractory disease. Ulcerative colitis is curable with performance of a total colectomy. Patients with UC may opt to have a colectomy to reduce the chance of developing colorectal cancer. Patients with CD may have affected areas of intestine resected. Unfortunately, CD may recur following surgical resection. Repeated surgeries may lead to significant malabsorption of nutrients and drugs consistent with development of short-bowel syndrome. 

Individuals with stage I to III colorectal cancer should undergo a complete surgical resection of the tumor mass with removal of regional lymph nodes as a curative approach for... 

An important demonstration of the efficacy of a MAb in minimal residual disease was achieved usiug MAb 17-lA (directed against the EGP-2 or EpCAM antigen as described previously) in patients with stage III colorectal cancer. Following surgical resection, MAb therapy reduced the overall death rate by 32% and the rate of recurrence by 23% [122]. 

L. Staib, H. Schirrmeister, S.N. Reske, H.G. Beger, Is (18)F-fluorodeoxyglucose positron emission tomography in recurrent colorectal cancer a contribution to surgical decision making. Am. J. Surg. 180(1) (2000) 1-5. 

Colorectal cancer (CRC) is the third most common cause of cancer-related death in women and men in the United States (4). Although surgical resection is the primary therapy for CRC, prognosis remains poor and not all patients are candidates for surgery. The current therapeutic options for patients with metastatic CRC (mCRC) are 5-fluorouracil (5-FU) based therapy regimens in combination with irinotecan (CPT-11) or oxaliplatin (5,6). 

Clinical Use. Levamisole (Ergamisol) is primarily used to treat colorectal carcinoma. Specifically, this drug is administered with fluorouracil (see Chapter 36) to prevent recurrence of colorectal cancer after surgical removal of the primary tumor.1... 

Adjuvant therapy differs for colon and rectal cancer because their natural history and recurrence patterns differ. Rectal cancer is more difficult to resect with wide margins, so local recurrences are more frequent than with colon cancer. Adjuvant RT plus chemotherapy is considered standard for stage 11 or 111 rectal cancer. Adjuvant chemotherapy is standard for stage 111 colon cancer and can be considered for high-risk stage II colon cancer. Adjuvant therapy is not indicated for stage I colorectal cancer because most patients are cured by surgical resection alone. 

Liver metastases from colorectal cancer Present surgical approach. Hepato-Gastroenterol. 2003 50 2067—2071... 

Treatment modalities for colorectal cancer include surgery, XRT, chemotherapy, immunotherapy, and new targeted molecular therapies. Surgery is the most important and deflnitive procedure associated with cure radiation therapy can be used to improve curability following surgical resection and to reduce symptoms and complications... 

Complete surgical resection of discrete hepatic, pulmonary, abdominal, or brain metastases in patients with colorectal cancer, if possible, may offer selected patients an opportunity to experience extended DPS. Patients who have from one to three small nodules isolated to the liver, lungs, or abdomen have the most favorable outcome. Up to 25% of patients will present with hepatic metastases at time of diagnosis, and 60% of patients with colorectal cancer wfll develop hepatic metastases sometime during the course of their disease. 

Colorectal cancer is one of the most common potentially lethal gastrointestinal diseases encountered in clinical practice and can be curable with proper management. In the United States in 1993, there were an estimated 152000 new cases of colorectal cancer and 57000 deaths from this disease [46]. Approximately 30-40% of patients with colorectal cancers are not candidates for aggressive surgical therapy because of distant metastases, extensive local tumor infiltration, poor general condition or refusal of the patient to undergo surgery. These are the patients who require... 

Atkin, G., Daley, F.M., Bourne, S., Glynne-Jones, R., Northover, J., and Wilson GD. (2006) The effect of surgically induced ischaemia on gene expression in a colorectal cancer xenograft model. Br. J. Cancer 94, 121-127. 

Colorectal cancer (12) Appropriate surgical treatment Chronic Surgery Underuse... 

Torisu M, Hayashi Y, Ishimitu T, Fujimura T, Iwasaki K, Katano M, Yamamoto H, Kimura Y, Takesue M, Kondo M, Nomoto K (1990) Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) administration after curative surgical operation of colorectal cancer. Cancer Immunol Imunother 31 261-268... 

Tumors not suitable for surgical resection for cure (HCC, colorectal cancer metastases approved by the regulatory authorities, metastases from other primaries can be treated accordingly with intention-to-treat but as yet without sufficient study basis)... 

Kemeny NE (1995) Regional chemotherapy of colorectal cancer. Eur J Cancer 31A 1271-1276 Kemeny NE, Atiq OT (1999) Non-surgical treatment for liver metastases. Baillieres Best Pract Res Clin Gastroenterol... 

Mariette D, Fagniez PL (1992) Hepatic metastasis of non-colorectal cancers. Results of surgical treatment. Rev Prat 42 1271-1275... 

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